A series of novel 1,2,3-triazole-functionalized pyrimidines were prepared by the reaction of 4-propargyl-substituted-5-bromo-2-chloro-6-methylpyrimidine with aryl azides via copper-catalyzed azide-alkyne cycloaddition reactions in the presence of phenylenediamine, as a ligand. This method offers the advan-tages of mild experimental conditions, operational simplicity, and good to high reaction yields. Furthermore, the synthesized compounds were screened against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis.

A useful and efficient procedure was obtained for the synthesis of 1,2,3-triazole-linked pyrimidines via click reaction of propynylated pyrimidine and aromatic azides in the presence of Mg-Al-LDH-immobilized-CuI with high-toexcellent yields. Moreover, the prepared catalyst was characterized by the FT-IR spectroscopy, XRD, BET, SEM, and ICP techniques. The developed synthetic technique offers numerous advantages such as a clean reaction, easy workup, high reaction yields, and short reaction time.

An efficient method is developed for the synthesis of 4-(3-arylprop-2-ynyloxy)-6-methyl-2-(methylthio)pyrimidines via palladium-catalyzed Sonogashira reactions of 4-methyl-2-(methylthio)-6-(prop-2-yn-1-yloxy)pyrimidine with electron-poor aryl iodides in acetonitrile at room temperature. Excellent yields of the products were obtained in reaction times of 9–11 h.