Background: Insomnia is one of the common sleep disorders in the elderly. Lack of adequate sleep has many consequences, such as fatigue, frustration and increased rate of mortality among them. The study was carried out to determine the effect of group reminiscence therapy on insomnia in older adults. Methods: This randomized controlled clinical trial was done on 72 older adults who referred to Sadoughi health care center in Kashan, Iran between August and November 2018.The subjects were recruited through convenience sampling and randomly allocated into two control and intervention groups. The reminiscence therapy was held twice a week, in a 4-week period for intervention group and the duration of each session varied between 1.5-2 hours. There was no intervention in control group. Data were collected using Mini-Mental State Examination (MMSE), and Insomnia Severity Index (ISI). Data was gathered three times; before intervention, immediately and one month after the intervention. Data were analyzed using Chi-Square, and Man-Whitney tests and repeated measures analysis in SPSS (v. 16.0, SPSS Inc., Chicago, IL, USA). Results: The mean score of insomnia decreased in intervention group after group reminiscence therapy (p<0.001); from 16±1.74 (before the intervention) to 11.27±2.09 (immediately after the intervention) and 11.38±1.93 (one month after the intervention), while the insomnia score had not noticeable change in control group. The intervention group showed significantly less insomnia scores over the time compared to control group (p < 0.05). Conclusions: Reminiscence therapy decreases the severity of insomnia in older adults.

Introduction: The role of phosphodiesterase (PDE) inhibitors in reducing neuropathic pains is uncertain. In this study, the antinociceptive effects of theophylline, milrinone, and tadalafil were investigated on sciatic nerve ligation-induced neuropathic pain (NP).Methods: Male mice (25-30 g) were purchased and housed in controlled environmental conditions before and during the experiments. The mice received identical diet and water ad libitum. Two weeks after sciatic nerve ligation, either theophylline (75 mg/kg), milrinone (4.5 mg/kg), or tadalafil (20 mg/kg) was intraperitoneally (IP) injected for either 1, 3, or 7 consecutive days. Antinociceptive effects were evaluated using the hot plate test. Negative controls received time course IP injections of saline (5 mL/kg). A single dose of imipramine (40 mg/kg,) was intraperitoneally administrated to the mice in the positive control group. Results: As was found for this study, a single-dose IP injection of either theophylline (75 mg/kg), milrinone (4.5 mg/kg), or tadalafil (20 mg/kg) on day 14th following sciatic nerve ligation induced significant antinociceptive effects at 30 minutes (P < 0.01), 60 minutes (P < 0.01), and 90 minutes (P < 0.05) compared to the control (saline– treated) animals. Accordingly, both 3- (on days 12–14) and 7-day (on days 8– 14) IP injections of tadalafil (20 mg/kg) induced significant antinociceptive effects at 30 minutes (P < 0.05), 60 minutes (P < 0.01), and 90 minutes (P < 0.01) after sciatic nerve ligation compared to the control (saline–treated) animals. However, the 3- and 7-day IP injections of theophylline and milrinone did not reveal any significant differences compared to the control group. Conclusion: Taken together, the results of this study suggested that selective PDE inhibitors that act predominantly on cGMP pathway, may contribute to the management of sciatic nerve ligation–induced pain.