We present a case of male, premature born child with multiple anomalies. The physical status was dominated by penile duplication, with additional, abortion scrotum in the median line, without palpable content and omphalocele with semi septum of the anus. By ultrasound examination of internal organs, we found a complex congenital heart anomaly, multiple anomalies in abdomen and micro calcifications in the central nervous system. General condition of the child required a prolonged mechanical ventilation and intensive care, so with clinical picture of liver failure at the age of 45 days occurred fetal outcome.

the clinical diagnosis of LS should be molecularly confirmed in the patient.

The most prevalent congenital heart defects for paediatric cardiologists to deal with have traditionally been cardiomyopathy (primary disease of the heart muscle), arrhythmia (irregular heartbeat), and acquired heart disease. More recently, most developed countries are also engaged in combatting fetal echocardiography.Rheumatic heart disease and Kawasaki disease are the two most common types of acquired disease in children. Rheumatic heart disease occurs in children aged 5-15 years, and Kawasaki disease is most common in those younger than 5 years. Both diseases represent inflammatory conditions. Kawasaki disease affects the lymph nodes, and blood vessels of the heart. Rheumatic disease affects the connective tissue, and causes inflammation of the joints, and especially inflammation of the heart.Bacterial infections can affect not only the valves of the heart, but also the heart muscle, and the lining of the heart. Cardiac valves can be affected by systemic diseases, rheumatoid arthritis, and lupus.

No abstract

Lethal and sublethal genetical factors, including Rh factor, represent endogenous risk factors of the pregnancy outcome. These factors are most frequently inherited in recessive way and they often lead to the negative outcome of pregnancies. They represent pregnancy (a prirori) risk of various degrees. Inheritance of Rh system blood groups is linked to chromosome 1 and it could be explained by two alternative theories; molecular Rh system genetics has not yet been completely explained. The first formal-genetic theory postulates three closely linked gene sites (loci C, D and E) while the second theory has a monogenic character (one locus with several allele genes). Data on 755 pregnancies, which were (for various reasons) estimated as increased risk pregnancies, were registered at Gynaecology Clinic, Clinical Centre of University of Sarajevo, during the period from 1989 to 1992. These data were collected from pregnant women who, according to the certain indications from their familiar and personal anamnesis, demanded genetic consultations. The result of investigation of the basic Rh system phenotype distribution shows no statistically significant difference between monitored pregnant women. This result is assumed as valid for both pregnant women and their partners. The same result is suggesting that the observed increased risk pregnancy samples do not significantly differ from the previously studied population samples. Therefore, it has been concluded that Rh factor is not closely related to the increased risk of individual pregnancy outcomes, that is, it does not have relevant influence on the observed reproduction parameters. This result is very interesting and deserves particular medical attention and further evaluation in the future, particularly considering known immunological phenomena resulting from relations between reproduction partners' belonging to the basic Rh system phenotypes.