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A simple and efficient approach has been developed to synthesise novel and functionalised 5H-chromeno[2,3-d] pyrimidines derivatives (4a-h). This approach entails treating 2-amino-3-cyano-4H-chromenes (3a-h) with formamidine acetate under microwave irradiations and solvent-free conditions. All structures of new compounds obtained in this study were characterised by IR, MS, 1H and 13C NMR analysis. Additionally, the synthesised compounds were investigated for their antibacterial and antioxidant potential. Compounds 3b, 3c, 3e, 4c and 4e showed significant activities. Keywords: 5H-chromeno[2,3-d] pyrimidine; 4H-chromene; solvent-free conditions; antioxidant activity; antibacterial activity

2-aminopyridines scaffolds are an important class of nitrogen heterocyclic compounds with a wide range of biological activities. Multicomponent reactions (MCRs) are useful methods for the construction of nitrogen heterocyclic compounds. In this context, syntheses of 2-aminopyridines derivatives via MCRs have attracted considerable attention in recent years. We present, in this work, a rapid and efficient synthesis of 2-aminopyridine derivatives, via the catalyst-free four-component method. This protocol provides a simple and practical approach to functionalized 2-aminopyridnes from readily available substrates under solvent-free conditions.