Infection due to Helicobacter pylori is a public health challenge worldwide as over 3 billion persons are infected with the bacterium globally. There is a serious need to update the knowledge on the epidemiology of this bacterial pathogen and its probable risks factors to generate intervention programs that will reduce the morbidity and mortality of infected individuals. This chapter evaluated the seromarkers of H. pylori infection and its predisposing factors among students of Nasarawa State University, Keffi, Central Nigeria. This study was done between June through August 2019; blood and stool specimens were collected from 400 students of the institution. Before the commencement of the study, ethical clearance and informed consent were retrieved and a structured questionnaire was administered to each participant. Specimens were screened for H. pylori antigen and antibody using rapid test kits (CTK Biotech, Inc., San Diego, USA and Biotest Biotech, China). Information obtained were analyzed using SSP version 2.80. P values <0.05 were reflected statistically significant. Out of the 400 students tested, 166 (41.5%) and 128 (32.0%) showed positive for anti-H. pylori IgG and Ag markers respectively. The antibody seromarker was higher in female while the H. pylori antigen was higher in males. Those students aged 21–30 years old reported the highest prevalence of the seromarkers while those of more than 41 years old had the least prevalence. Location, type of toilet facility and place of residence were statistical associated between H. pylori antigen (P < 0.05). There was a statistically significant association between anti-H. pylori IgG and the sources of water of the students (P < 0.05). This is the first public report that has successfully reported the prevalence of these seromarkers among students of a tertiary institution in Nasarawa state. The overall outcomes of this study stressed the need for student-based intervention programs to stem the transmission of this infection in Nasarawa State, Nigeria.