Background: Nurses had play a multidisplinary role as a direct care provider who must provide competent nursing care based upon evidence base research finding for women undergoing cesarean section. Aim: evaluate knowledge & practice of nurses regarding care of women with cesarean section Study Design: descriptive design. Setting: the study was conducted at 6 inpatient units' at maternity hospital Ain shams University. Sampling: purposive sample included 38 nurses. Tools of data collection: were structured interviewing questionnaire sheet & observational checklist. Results: the study finding revealed that 68.4% had poor knowledge and 57.9% had poor practice regarding care of cesarean section. Conclusion: there were more than two third of study sample had incorrect knowledge related to cesarean section and slightly more than half of them had incorrect practice. Recommendations provide periodic in service -training program regarding cesarean section care. Key wards: cesarean section, nurses' knowledge, practical skills. Introduction:Cesarean section (CS) is an important lifesaving operation when vaginal delivery might pose a risk to a mother or baby. However, if not medically indicated or if performed under suboptimal conditions, CS can cause maternal and fetal complications, including death. According to the World Health Organization (2015), at the population level, CS rates higher than 10 percent are not associated with reductions in maternal and newborn mortality rates.