One of the most important conditions for individuals to be happy and productive in workplaces is job satisfaction.In this study, it was aimed to determine the levels of job satisfaction in physicans and nurses who worked in hospitals in Edirne and to evaluate the effects of potential influencing factors on job satisfaction. The population of the study was composed of a total of 1376 individuals. The sample group was composed of a total of 385 healthcare staffs including 192 physicians and 193 nurses (28% of the population). The data were collected using a questionnaire form and Minnesota Job Satisfaction Scale and evaluated by SPSS (Statistical Package for Social Sciences) 20.0 package program. Job satisfaction levels were found better in the healthcare staffs who worked in private hospital. When assessed by profession, the highest level of job satisfaction was found in academic member. This study was found that 82% of the health staffs reported that they did not feel safe while working, 75% were exposed to verbal or physical abuse. When the satisfaction of the participants related to the institution where they worked and the occupation they had was examined, it was observed that approximately 37% reported that they thought to leave the institution where they worked and 25% even reported that they thought quitting their jobs. The general job satisfaction was better in individuals who were experts in their areas, who worked in private hospital, who loved their profession, whose working hours were regular, who felt themselves safe in their institutions and who worked free from violence. The worst level of job satisfaction was found in general practitioners. The job satisfaction of healthcare staffs who thought that the performance-based payment system applied in Turkey was unfair was low.