Melanoma is an aggressive malignancy, and early diagnosis and treatment can reduce mortality in patients. A new or changing lesion is the most common warning sign of melanoma. In amelanotic tumors, diagnosis may be delayed. Amelanotic melanoma is a form of melanoma in which malignant cells have little or no pigment. Amelanotic melanoma is classically described as skin coloured but a subset of these tumors are red, pink or erythematous. Typical early lesions present as asymmetrical macular lesions. FNAC may show varied cytomorphology ranging from epithelioid to spindled to plasmacytoid pleomorphic cells with marked anisonucleosis and eosinophilic to basophilic cytoplasm with intranuclear pseudoinclusions and cytoplasmic vacoulations admixed with bi-and multinucleate giant cells. We present a case series of varied presentation of amelanotic melanoma with its cytomorphological features.

Filariasis is a major public health problem in developing countries, and the diagnosis is conventionally made by demonstrating microfilariae in the peripheral blood smear. However, microfilariae have been incidentally detected in fine needle aspirates of various lesions in clinically unsuspected cases of filariasis with absence of microfilariae in the peripheral blood. Microfilariae in cytological smears of malignant neoplasms is a chance finding. Cytology can be an effective tool for detection of asymptomatic filariasis and malignancy, thus helping in disease eradication and mortality. There are reports of coexistence of microfilaria with Ewing’s sarcoma, squamous cell carcinoma of maxillary antrum and dentigerous cyst by different cytopathologists. Here we present a rare case of microfilariae in a cytological aspirate smear from left knee swelling with a malignant osteogenic tumor, osteosarcoma.