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Background Depression is associated with reduced heart rate variability (HRV) in healthy and cardiac samples, which may be accounted for by physical fitness. In a small sample of cardiac patients, activity and fitness levels attenuated the relationship between HRV and depression. In the current study of heart failure (HF) patients, we hypothesized that depressive symptoms and HRV would be inversely related and physical fitness would attenuate this association. Purpose To determine if previous associations among depressive symptoms, physical fitness, and HRV would replicate in a sample of HF patients. Methods The sample consisted of HF patients (N = 125) aged 68.55 ± 8.92 years, 68.8% male, and 83.2% Caucasian. The study was cross-sectional and a secondary analysis of a nonrandomized clinical trial (Trial Identifier: NCT00871897). Depressive symptoms were evaluated using the Beck Depression Inventory (BDI)-II, fitness with the 2 min step test (2MST), and HRV during a 10 min resting laboratory psychophysiology protocol. The dependent variable in hierarchical linear regressions was the root mean square of successive differences. Results Controlling for sex, age, β-blocker use, hypertension, and diabetes, higher BDI-II scores significantly predicted lower HRV, β = −.29, t(92) = −2.79, p < .01. Adding 2MST did not attenuate the relationship in a follow-up regression. Conclusion Depressive symptoms were associated with lower HRV in HF patients, independent of physical fitness. Given the prevalence of depression and suppressed HRV common among HF patients, interventions addressing depressive symptoms and other predictors of poor outcomes may be warranted.

Objective: Notwithstanding the efficacy of bariatric surgery in reducing the negative sequelae of obesity, psychological factors may play a significant role in long-term weight maintenance following surgery. Previous research on these factors has shown mixed outcomes, indicating the need for further study in samples undergoing bariatric surgery. Method: This study evaluated archival data for 194 patients from a single-payer system for a 60-month period following bariatric surgery to examine how presurgical scores on the Personality Assessment Inventory predict body mass index (BMI) over time. Follow-up data was available on 97% of these patients at 12 months and 62% of these patients at 60 months. Hierarchical linear modeling was used to predict BMI based on demographic and psychopathology factors using linear and nonlinear coefficients while controlling for initial BMI. Results: Results showed that Personality Assessment Inventory scales assessing anxiety-related disorders, mania, and alcohol problems showed a relationship to BMI outcomes over time. Contrary to expectations, moderate elevations on anxiety-related disorders and mania were associated with a greater initial linear trend for BMI decrease, with a steeper slope for weight regain after approximately 3 years. Patients endorsing any scores above the minimum on the alcohol problems scale showed poorer BMI outcomes. Conclusions: This study extends previous research on psychological factors and weight outcomes over time among patients undergoing bariatric surgery. In contrast to a focus on clinical elevations when using broadband measures of psychopathology, these results suggest a more nuanced pattern of weight loss and subsequent regain associated with certain subclinical elevations.

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Heart failure (HF) is associated with high rates of depression. In turn, depression is associated with reduced heart rate variability (HRV), a marker of parasympathetic dysfunction and poorer cardiac outcomes. Cognitive impairment--especially executive dysfunction--is also highly prevalent in HF, but it is unknown whether executive function (EF) impacts the depression-HRV relationship. The primary objective of this paper is to examine whether EF moderates the relationship between depression and HRV in HF. Participants were 109 HF patients. Depressive symptoms were measured using the Beck Depression Inventory-II. EF was assessed using a composite of age-adjusted T scores on the Frontal Assessment Battery, Trail Making Test B, and Stroop Color Word subtest. Parasympathetic function was assessed using resting high frequency HRV (HF-HRV). Multiple hierarchical regression was used to conduct BDI × EF moderation analyses. BDI scores were associated with reduced resting HF-HRV (p < .05). No main effects were detected between EF and resting HF-HRV (p > .05). However, EF moderated the relationship between BDI scores and resting HF-HRV (β = 0.59, p < .01). Simple slope analyses revealed that among participants with poorer EF, higher BDI scores were associated with lower resting HF-HRV (p < .001). Structural brain changes common in HF may contribute to lower EF, increased depression, and poorer autonomic functioning. Alternatively, the results may indicate that individuals with intact EF engage in self-care strategies that negate the detrimental impact of depression on autonomic function. Additional work is needed to clarify these possibilities and the potential benefits of treating depression in HF patients with different cognitive abilities.