Purpose The purpose of this paper is to review previous research studies on mathematical models for entropy generation in the magnetohydrodynamics (MHD) flow of nanofluids. In addition, the influence of various parameters on the velocity profiles, temperature profiles and entropy generation was studied. Furthermore, the numerical methods used to solve the model equations were summarized. The underlying purpose was to understand the research gap and develop a research agenda. Design/methodology/approach This paper reviews 141 journal articles published between 2010 and 2022 on topics related to mathematical models used to assess the impacts of various parameters on the entropy generation, heat transfer and velocity of the MHD flow of nanofluids. Findings This review clarifies the application of entropy generation mathematical models, identifies areas for future research and provides necessary information for future research in the development of efficient thermodynamic systems. It is hoped that this review paper can provide a basis for further research on the irreversibility of nanofluids flowing through different channels in the development of efficient thermodynamic systems. Originality/value Entropy generation analysis and minimization constitute effective approaches for improving the performance of thermodynamic systems. A comprehensive review of the effects of various parameters on entropy generation was performed in this study.