Intravenous iron therapy without rhEPO substantially reduced NT-proBNP and inflammatory status in anemic patients with CHF and moderate CRF. This situation was associated with an improvement in LVEF, NYHA functional class, exercise capacity, renal function, and better quality of life.

Intravenous iron treatment was associated with improved myocardial functional parameters and cardiac dimensions in patients with anaemia and chronic kidney disease.

A large body of evidence indicates that proteinuria is a strong predictor of morbidity, a cause of inflammation, oxidative stress and progression of chronic kidney disease, and development of cardiovascular disease. The processes that lead to proteinuria are complex and involve factors such as glomerular hemodynamic, tubular absorption, and diffusion gradients. Alterations in various different molecular pathways and interactions may lead to the identical clinical end points of proteinuria and chronic kidney disease. Glomerular diseases include a wide range of immune and nonimmune insults that may target and thus damage some components of the glomerular filtration barrier. In many of these conditions, the renal visceral epithelial cell (podocyte) responds to injury along defined pathways, which may explain the resultant clinical and histological changes. The recent discovery of the molecular components of the slit diaphragm, specialized structure of podocyte-podocyte interaction, has been a major breakthrough in understanding the crucial role of the epithelial layer of the glomerular barrier and the pathogenesis of proteinuria. This paper provides an overview and update on the structure and function of the glomerular filtration barrier and the pathogenesis of proteinuria, highlighting the role of the podocyte in this setting. In addition, current antiproteinuric therapeutic approaches are briefly commented.

In the last couple of decades, there has been an unparalleled growth in number of people who can afford motorized vehicles. This is increasing the number of vehicles on roads at an alarming rate and existing infrastructure and conventional methods of traffic management are becoming inefficient both on highways and in urban areas. It is very important that our highways are up and running 24/7 as they not only provide a passage for human beings to move from one place to another, but also are the most important mode for intercity or international transfer of goods. There is an utter need of adapting the new world order, where daily processes are driven with the help of innovative technologies. It is highly likely that technological advancements like autonomous or connected vehicles, big data and the Internet of things can provide highway operators with a solution that might resolve unforeseeable challenges. This investigative exploratory research identifies and highlights the impact of new technological advancements in the automotive industry on highways and highway operators. The data for this research was collected on a Likert scale type online survey, from different organizations around the world (actively or passively involved in highway operations). The data was further tested for its empirical significance with non-parametric binomial and Wilcoxon signed rank tests, supported by a descriptive analysis. The results of this study are in line with theoretical and conceptual work done by several independent corporations and academic researchers. It is evident form the opinions of seasoned professionals that these technological advancements withhold the potential to resolve all potential challenges and revolutionize highway operations.