This review is concerned with modern trends in the use of electrochemically induced chain reactions in cascade and multicomponent electroorganic synthesis. The review summarizes the data on the use of electrochemically induced chain reactions in cascade and multicomponent organic synthesis, which were published mainly in the last decade.

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Potassium fluoride-catalyzed solvent-free multicomponent reaction of aldehydes, N,N′-dialkyl barbiturates and malononitrile results in the fast (15 min) and efficient (yields 89–95%) formation of substituted pyrano[2,3-d]pyrimidines. The improved synthetic methodology for this class of bioactive compounds is important from the viewpoint of diversity-oriented large-scale processes and represents an environmentally benign solvent-free synthetic concept for multicomponent reactions strategy.

A pot, atom and step economy (PASE) synthesis of new 5-C substituted 2,4-diamino-5H-chromeno [2,3-b]pyridine-3-carbonitriles was carried out. This process involves the one-pot, pseudo four-component reaction of salicylaldehydes, malononitrile, 1,3-cyclohexanediones and Et 3 N as a catalyst in acetonitrile at reflux. This novel one-pot reaction provides an effective and convenient way to 5-C cyclohexyl-functionalized chromeno[2,3b]pyridines, which are promising compounds for different biomedical applications. The procedure utilizes readily available reagents, it is easily carried out and the work up is not complicated. 2,4-diamino-5-(2-hydroxy-6-oxocyclohex-1-en-1yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles are crystallized directly from the reaction mixture and the isolation includes only filtration. Molecular docking studies of the synthesized 2,4diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles were also carried out to elucidate their relationship with the binding pockets of the mitogen activated protein kinase (MK).

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