In the Russian Federation, the traditional mechanisms of inspection control are changing and industrial safety measures are being modernized. Operator mistakes are one of the most common causes of industrial accidents. The practice of the introduction of interactive training complexes indicates formation of behavior skills in normal and non-standard (emergency) modes of installations work during the training, thereby reducing the the possibility of accidents caused by personnel and, as a result, increases the safety and efficiency of production. The article is devoted to the development of technological processes operators simulators used to train operational personnel skills of technological processes management of industrial enterprises. Describes the main requirements to the computer equipment and the development of their mathematical support. The basic concepts and methods of analytical and simulation modeling of technological systems are given. The principles of application of neural networks as one of the most promising methods of complex technological processes modeling in the development of control systems and simulators of industrial plants are considered in detail. Various aspects of process modeling and the main advantages of using training simulators to improve production efficiency are considered.