Key Points Ibrutinib but not zanubrutinib induces shedding of GPIb-IX complex in an ADAM17-dependent manner; GPIX has not been shown previously. Ibrutinib, but not zanubrutinib, induces shedding of integrin αIIbβ3 by an unknown sheddase.

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Introduction: Osteoarthritis (OA) is a chronic disorder and the most common form of arthritis. OA leads to the breakdown of tissues and cartilage and the loss of combined function, causing symptoms of pain, stiffness, reduced physical function and limited movement. Incidence rates vary according to region and ethnicity. Materials and Methods: A cross-sectional study involving the general population of Sudair was conducted to assess the awareness and knowledge levels of OA from June to December 2020. In all, 387 residents participated, and data were collected using a pre-tested questionnaire. Data were analysed by SPSS, and appropriate statistical tests such as One-sample t-test, Chi-squared and Fisher's exact tests were applied for quantitative and qualitative variables. Results: Almost 80% of the sample belonged to the age group of 18–50 years. More than 50% were men. Overall, 199 (51.42%) participants had moderate knowledge of OA, 134 (34.63%) had poor knowledge, and only 14% had adequate knowledge. Men had significantly poorer knowledge than women (P = 0.018). Participants with a previous history and family history of OA had significantly more knowledge than the healthy participants with previous experience of OA (P < 0.001). Conclusion: The majority of the participants who lived in Sudair had moderate knowledge of OA. Previous knowledge of OA because of previous diagnosis or family history of OA led to improved awareness of OA.

Currently, new advancements in the area of nanotechnology opened up new prospects in the field of medicine that could provide us with a solution for numerous medical complications. Although a several varieties of nanoparticles is being explored to be used as nanomedicines, cerium oxide nanoparticles (CeO2 NPs) are the most attractive due to their biocompatibility and their switchable oxidation state (+3 and +4) or in other words the ability to act as prooxidant and antioxidant depending on the pH condition. Green synthesis of nanoparticles is preferred to make it more economical, eco-friendly, and less toxic. The aim of our study here is to formulate the CeO2 NPs (CeO2 NPs) using Morinda citrifolia (Noni) leaf extract and study its optical, structural, antibacterial, and anticancer abilities. Their optical and structural characterization was accomplished by employing X-ray diffractography (XRD), TEM, EDAX, FTIR, UV-vis, and photoluminescence assays. Our CeO2 NPs expressed strong antibacterial effects against Gram-positive S. aureus and S. pneumonia in addition to Gram-negative E. coli and K. pneumonia when compared with amoxicillin. The anticancer properties of the green synthesized CeO2 NPs against human acute lymphoblastic leukemia (ALL) MOLT-4 cells were further explored by the meticulous study of their ability to diminish cancer cell viability (cytotoxicity), accelerate apoptosis, escalate intracellular reactive oxygen species (ROS) accumulation, decline the mitochondria membrane potential (MMP) level, modify the cell adhesion, and shoot up the activation of proapoptotic markers, caspase−3, −8, and −9, in the tumor cells. Altogether, the outcomes demonstrated that our green synthesized CeO2 NPs are an excellent candidate for alternative cancer therapy.