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To determine the incidence and causes of increased intraocular pressure (IOP) after pars plana vitrectomy with the vitrophage, we studied 118 eyes under-going vitrectomy during a one-year period. Fifty-one (43%) were in diabetic patients; 67 (57%) were in nondiabetics. Of the entire group, 33 (28%) developed a postoperative increase in IOP, which was defined as a rise in IOP of at least 10 mm Hg above the preoperative level by applanation tonometry. Of the diabetic eyes 25 (49%) developed increased IOP; 11 (22%) of these eyes required surgical intervention for control of IOP. Of the nondiabetic eyes eight (12%) developed increased IOP postoperatively; all were either transiently elevated or medically controllable. Postoperative rubeosis iridis occurred only in diabetic eyes.

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