Many functional connectivity studies based on electrophysiological measurements, such as electro-and magnetoencephalography (EEG/MEG), start their investigations by extracting a narrowband representation of brain activity time series, and then computing their envelope amplitudes and instantaneous phases, which serve as inputs to subsequent data processing. The two most popular approaches for obtaining these narrowband amplitudes and phases are: bandpass filtering followed by Hilbert transform (we call this the Hilbert approach); and convolution with wavelet kernels (the wavelet approach). In this work, we investigate how these two approaches perform in detecting the phenomenon of phase-amplitude coupling (PAC), whereby the amplitude of a high-frequency signal is driven by the phase of a lowfrequency signal. The comparison of both approaches is carried out by means of simulated brain activity, from which we run receiver operating characteristic (ROC) analyses, and of experimental MEG data from a visuomotor coordination study. The ROC analyses show that both approaches have comparable accuracy, except in the presence of interfering signals with frequencies near the high-frequency band. As for the visuomotor data, the most noticeable impact of the choice of approach was observed when evaluating task-based changes in PAC between the delta (2-5 Hz) and the high-gamma (60-90 Hz) frequency bands, as we were able to identify widespread brain areas with statistically significant effects only with the Hilbert approach. These results provide preliminary evidence of the advantages of the Hilbert approach over the wavelet approach, at least in the context of PAC estimates.
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