Although collaborative care is increasingly being implemented in the treatment of various diseases, there are currently no related studies on its effects in endometrial cancer patients after laparoscopic treatment. Thus, this study is aimed at investigating the significance of an integrated medical and nursing care model for women with gynecologic malignant tumors who underwent laparoscopic treatment. The patients were randomly divided into a medical-nursing integrated nursing group (study group) and a general nursing group (control group). Their serum carbohydrate antigen 19-9 (CA19-9), human epididymal protein 4 (HE4), CA15-3, and CA125 levels were measured at admission, 7 and 15 days after admission, and 30 days after discharge. Their first postoperative flatulence time, eating time, and hospitalization duration were recorded, and the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate the psychological state of the patients. A questionnaire survey was also used to evaluate their satisfaction with nursing. Adverse events within 2 years of follow-up were recorded. The results showed that the clinical performance of the study group was significantly better than that of the control group. Further, the study group demonstrated significantly lower serum tumor marker levels, SAS score, SDS score, and incidence of adverse events at 7 and 15 days after admission and 30 days after discharge and higher nursing satisfaction than the control group. Thus, the collaborative nursing mode might be more conducive to the recovery of women who have underwent laparoscopic treatment for gynecologic malignant tumors than normal routine nursing.

The aim of this study was to investigate the association of mutations in the E2/NS1 [hypervariable regions 1 and 2 (HVR1 and HVR2)] and NS5A regions of the hepatitis C virus (HCV) genome and the effectiveness of interferon (IFN) therapy, and assess whether the degree of heterogeneity of HCV quasispecies predicts response to IFN treatment. Fourteen patients infected with HCV genotype 1b (HCV-1b) who were treated with pegylated IFN-α-2a and ribavirin for 24 weeks, were studied. E2/NS1 and NS5A gene segments were amplified by reverse-transcription polymerase chain reaction. HCV quasispecies heterogeneity in the E2/NS1 region was determined by cloning and sequencing. Mutations in the NS5A region were detected by direct sequencing. The heterogeneity of HCV quasispecies in the HVR1 was significantly greater in the non-responder group than in the responder group, but was not significant for HVR2 or NS5A. The correlation between mutations in IFN sensitivity-determining region (ISDR, NS5A2209-2248) and IFN sensitivity could not be supported. The degree of quasispecies heterogeneity in HVR1, but not in HVR2 and NS5A, may be predictive of response to IFN therapy. An ISDR may not apply to patients infected with HCV-1b.

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