No abstract

Amyloid β-peptide (Aβ) misfolding aggregates with β-sheet structures and surplus reactive oxygen species (ROS) are both considered to be the culprit of neuronal toxicity in Alzheimer’s disease (AD). Therefore, modulating the misfolding mode of Aβ and inhibiting ROS simultaneous has become an important method for anti-AD. Herein, a nanoscale manganese-substituted polyphosphomolybdate (H2en)3[Mn(H2O)4][Mn(H2O)3]2[P2Mo5O23]2·14.5H2O (abbreviated as MnPM) (en = ethanediamine) was designed and synthesized by single crystal to single crystal transformation method. MnPM can modulate the β-sheet rich conformation of Aβ aggregates, and thus reduce the formation of toxic species. Moreover, MnPM also possesses the ability to eliminate the free radicals produced by Cu2+-Aβ aggregates. It can inhibit the cytotoxicity of β-sheet-rich species and protect synapses of PC12 cells. MnPM combines the conformation modulating ability of Aβ and anti-oxidation ability, which makes a promising multi-funcational molecular with a composite mechanism for the new conceptual designing in treatment of such protein-misfolding diseases.

No abstract

The novel Ru–NiMoO4–NF catalysts were fabricate through simple experimental strategy, which exhibited outstanding hydrogen evolution reaction performances in alkaline.

Summary Polyhydride electrocatalysts integrated directly into metal substrates have attracted attention because they can provide high electrochemical specific surface area and excellent mechanical properties. In this work, through the classical hydrothermal method and subsequent phosphating procedure, we synthesized for the first time an electrocatalyst with a pyramid‐shaped MnCO3 as the main structure, P and Co as co‐doping elements, named Co, P‐MnCO3, and used it as hydrogen evolution reaction (HER). The experimental results show that the excellent catalytic activity in alkaline media, with current densities of 10 and 200 mA∙cm−2 at 61 mV and 158 mV and low overpotentials, which are better than P‐Co (108/234 mV) and P‐MnCO3 (175 mV/340 mV), etc. it has more electrochemically active sites, faster charge transfer rate and lower resistance. The excellent electrochemical properties benefit from the unique highly active binary Co, P‐MnCO3 pyramid brick sites shortened the ion transfer distance and optimized synergistic effect between the doped metal elements (Co,P between MnCO3), the porous connection between Co, P‐MnCO3 and the high conductivity substrate, increased the electron‐transfer efficiency between the substrate and material, accelerating the conversion of H+ to H2; facilitated the release of bubbles and provided excellent mechanical properties for improved catalyst stability. This work provides a new idea for the synthesis of multi‐element electrocatalysts.