Genetic factors play an important role in the pathogenesis of diabetic retinopathy (DR). While many studies have focused on genes that increase susceptibility to DR, herein, we aimed to explore genes that confer DR resistance. Previously, we identified Hmg CoA reductase degradation protein 1 (SYVN1) as a putative DR protective gene via gene expression analysis. Transgenic mice overexpressing SYVN1 and wild-type (WT) mice with streptozotocin-induced diabetes were used in this experiment. Retinal damage and vascular leakage were investigated 6 months after induction of diabetes by histopathological and retinal cell apoptosis analyses and by retinal perfusion of fluorescein isothiocyanate-conjugated dextran. Compared with diabetic WT mice, diabetic SYVN1 mice had significantly more cells and reduced apoptosis in the retinal ganglion layer. Retinal vascular leakage was significantly lower in diabetic SYVN1 mice than in diabetic WT mice. The expression levels of endoplasmic reticulum (ER) stress-related, pro-inflammatory, and pro-angiogenic genes were also analyzed. Lower expression levels were observed in diabetic SYVN1 mice than in WT controls, suggesting that SYVN1 may play an important role in inhibiting ER stress, chronic inflammation, and vascular overgrowth associated with DR. Thus, these results strongly supported our hypothesis that SYVN1 confers DR resistance.

Steam boiler supplies steam of certain quality in industry process according to the changes of load. It is important of most power plants and has been concerned with analyzing power system dynamics in various works. Drum water level is one of the main processes in the boiler. Because of the phenomenon of false water level, three measurement signals including drum water level, water supply flow and steam flow are introduced. In this paper three impulses Cascade control system with fuzzy PID control is presented, and simulation is performed based on MATLAB.

In this paper, the microscopic features of damage and texture of a wheel tread in high-speed rail were investigated by EBSD. The microscopic sample was cut from the wheel tread zone of a used high-speed rail wheel. It was found from the microscopic investigation that the density of austenite distribution is increased near the wheel tread, and the damage voids distribute far away from the wheel tread zone. The texture analysis with two magnify zone indicated that there exists large amount of twin-crystal within the ferrite in the dimension of 20 micrometer, and the dimension of austenite and martensite decreases in the edge zone of the wheel tread.

Archard wear theory, which describled the relationship between wear volume and material hardness, coasting distance and loading, was the classical theory of tribology problem. According to Archard wear theory, bionic lead rail was compared with ordinary lead rail based on ABAQUS software in the same conditions. Friction and wear property of bionic lead rail were studied, including the maximum contact surface, the distribution of working point of friction force and transformation law of friction force. The results indicated that the maximum contact surface of bionic friction pair decreased obviously and the variation of contact surface was steady. The distribution of working point of friction force for ordinary lead rail was relatively concentration. The distribution of working point of friction force for bionic lead rail was relatively dispersion. Friction force for bionic friction pair decresed to some extent, but the peak friction force was relatively larger.