Asymmetrical growth of the vertebrae has been implicated as one possible etiologic factor in the pathogenesis of adolescent idiopathic scoliosis. The longitudinal vertebral growth derives from the endochondral ossification of the vertebral growth plate. In the present study, the growth plates from the convex and concave side of the vertebrae were characterized by the method of histology and immunohistochemistry to evaluate the growth activity, cell proliferation, and apoptosis. Normal zoned architectures were observed in the convex side of the growth plate and disorganized architectures in the concave side. The histological grades were significantly different between the convex and the concave side of the growth plate in the apex vertebrae (P < 0.05). The histological difference was also found significant statistically between end vertebrae and apex vertebrae in the concave side of vertebral growth plates (P < 0.05). The proliferative potential indexes and apoptosis indexes of chondrocytes in the proliferative and hypertrophic zone in the convex side were significantly higher than that in the concave side in the apex vertebral growth plate (P < 0.05). There was a significant difference of the proliferative potential index (proliferating cell nuclear antigen, PCNA index) between convex side and concave side at the upper end vertebra (P < 0.05). The difference of the proliferative potential index and apoptosis index were found significant statistically in the concave side of the vertebral growth plate between end vertebrae and apex vertebrae (P < 0.05). The same result was also found for the apoptosis index (terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate biotin nick end labeling assay, TUNEL index) in the convex side of vertebral growth plate between end vertebrae and apex vertebrae (P < 0.05). Some correlation were found between radiographic measurements and proliferation and apoptosis indexes. The difference in histological grades and cellular activity between the convex and concave side indicated that the bilateral growth plate of the vertebrae in AIS patients have different growth kinetics which may affect the curve progression.

Background: APMCF1 is a novel human gene first cloned from apoptotic MCF-7 cells. Our previous study found ectogenic APMCF1 could induce G1 arrest in hepatocarcinoma cell line HHCC. In order to search its broad expression profile for further understanding of its mechanism in tumor, we investigated a subcellular location of APMCF1 and performed an immunohistochemistry study including various tumor and normal tissues. Discovery from the expression characterization of AMPCF1 may have applicability in the analysis of its biological function in tumor.

Objective: To investigate the effect of out-of-hospital extended nursing on the compliance behaviors and therapeutic effect of brace treatment of patients with idiopathic scoliosis. Methods: 54 patients with idiopathic scoliosis between February 2015 and December 2017 were randomly divided into control group and observation group. Patients in the control group received pelvic suspension traction, gymnastic exercises, and brace wear at discharge, on the basis of which patients in the observation group were added with extended care outside the hospital. The compliance behaviors and the changes of scoliosis angle (Cobb angle) of patients in the 2 groups were evaluated. Results: Compared with the control group, patients in the observation group had better compliance behaviors in completion status of functional exercise (χ 2 =5.594, P=0.018), brace wear (χ 2 =6.171, P=0.013), subsequent visit on time (χ 2 =9.247, P=0.002). Cobb angle was improved significantly in both groups at the last follow-up comparedwith that on admission, and the improvement was more significantly in the observation group (P<0.001). Conclusion:Through the implementation of out-of-hospital extended nursing, the compliance behaviors and clinical effect of brace treatment for idiopathic scoliosis patients are obviously improved, and this active nursing model is worth popularizing in clinic. and the clinical effect was satisfactory, which was reported below.

A note about the cyclotomic polynomial Φ pq (x) and some related results ZHU Feng-xiang QI Wen-feng Abstract. The expression of cyclotomic polynomial Φpq(x) is concerned for a long time. A simple and explicit expression of Φpq(x) in Z[x] has been showed. The form of the factors of Φpq(x) over F2 and the upper, lower bounds of their Hamming weight are provided.lower bounds of their Hamming weight are also provided. We present an example in which the bounds established in Theorem 3 are attained. However, in most cases the bound can not be reached. It is worth more researches.