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Active matrix (AM) mini-LED backlight units (BLUs) based on amorphous silicon (a-Si) thin-film transistor (TFT) on a glass substrate for 75-inch 8K liquid crystal displays (LCDs) are developed, with each consisting of 5184 local dimming (LD) zones. The 75-inch 8K LCDs perform a high dynamic contrast ratio of 1,000,000:1 and high typical brightness of more than 1000 nits with 10% capable screen area. In addition, the LCDs show an excellent high dynamic range (HDR) and a real black state, which are comparable to that of other high-end displays (dual cells and organic light-emitting diode displays [OLEDs]). Also, the mini-LED BLUs feature a low fabrication cost.

Intratumoral hypoxia extremely limits the clinic applications of photodynamic therapy (PDT). Endoperoxides allow thermally releasing singlet oxygen (1O2) in a defined quantity and offer promising opportunities for oxygen-independent PDT treatment of hypoxic tumors. However, previous composite systems by combining endoperoxides with photothermal reagents may result in unpredicted side effects and potential harmful impacts during therapy in vivo. Herein, we de novo design an all-in-one polymer carrier, which can photothermally release 1O2. The strategy has been demonstrated to effectively enhance the production of 1O2 and realize the photodamage in vitro, especially in hypoxic environment. Additionally, the polymer carrier accumulates into tumor after intravenous injection via the enhanced permeation and retention effects and accelerates the oxygen-independent generation of 1O2 in tumors. The oxidative damage results in good inhibitory effect on tumor growth. Realization of the strategy in vivo paves a new way to construct photothermal-triggered oxygen-independent therapeutic platform for clinical applications.