In situ generation of 5-formylcytosine (5fC) in nucleosome core particles (NCPs) reveals that 5fC leads to essential DNA-protein crosslinks (DPCs). Mechanistic studies using chemical models and mutated histones demonstrate that DPCs form reversibly between the formyl function of 5fC and primary amines on histones. These results suggest that DPC formation from 5fC in chromatin occurs in addition to its role in DNA demethylation.

Skin-mountable physical sensors that can individually detect mechanical deformations with high strain sensitivity within a broad working strain range and temperature variations with accurate temperature resolution are a sought-after technology. Herein, a stretchable temperature and strain dual-parameter sensor that can precisely detect and distinguish strain from temperature stimuli without crosstalk is developed, based on a printable titanium carbide (MXene)-silver nanowire (AgNW)-PEDOT:PSStellurium nanowire (TeNW) nanocomposite. With this dualparameter sensor, strain and temperature are effectively transduced into electrically isolated signals through the electrically conductive MXene-AgNW and thermoelectric PEDOT:PSS-TeNW components, respectively. In addition, the synergistic effect between the MXene nanosheets and PEDOT:PSS also greatly enhances the stretchability and sensitivity of the sensing devices. These properties enable the nanocomposite to decouple responses between temperature and strain stimuli with an accurate temperature resolution of 0.2 °C and a gauge factor of up to 1933.3 in a working strain range broader than 60%.

Thermoelectric (TE) technology provides a new way to directly harvest and convert the heat continuously released from the human body. The greatest challenge for TE materials applied in wearable TE generators is compatible with the constantly changing morphology of the human body while offering a continuous and stable power output. Here, a stretchable carboxylic single-walled carbon nanotube (SWNT)-based TE fiber is prepared by an improved wetspinning method. The stable Seebeck coefficient of the annealed carboxylic SWNT-based TE fiber is 44 μV/K even under the tensile strain of ∼30%. Experimental results show that the fiber can continue to generate constant TE potential when it is changed to various shapes. The new stretchable TE fiber has a larger Seebeck coefficient and more stretchability than existing TE fibers based on the Seebeck effect, opening a path to using the technology for a variety of practical applications.

emerged as a next-generation technology that may find significant applications in applications where bendability, stretchability, wearability, portability, and lightness are needed. [1][2][3] Advanced fibers with integrated functionalities (i.e., conductivity) are of great interest for achieving wearable high-performance textile fabrics. Robustness, a rare yet important property allowing a system to maintain a stable structure and function against uncertainty perturbations, is highly required for wearable textile electronics. [4,5] In practical use, textile electronics are generally conformably attached or worn on the human body. Human motion is accompanied by irregular skin deformations that inevitably stretch or bend the textile electronics. Thus, robust textile electronics must function unalterably when disturbed by variable strain or stress. [6][7][8] To this end, functional fibers with intrinsically high robustness and multifunctionality may provide advanced fabric materials for achieving textile electronics with strain-unperturbed performance. However, achieving high-performance multifunctional fibers with high structural robustness and high damage resistance against strain remains a grand challenge. [3,9,10] From the viewpoint of material science, the robustness and multifunctionality of synthetic fibers are usually mutually Textile electronics are needed that can achieve strain-unaltered performance when they undergo irregular and repeated strain deformation. Such strainunaltered textile electronics require advanced fibers that simultaneously have high functionalities and extreme robustness as fabric materials. Current synthetic nanocomposite fibers based on inorganic matrix have remarkable functionalities but often suffer from low robustness and poor tolerance against crack formation. Here, we present a design for a high-performance multifunctional nanocomposite fiber that is mechanically and electrically robust, which was realized by crosslinking titanium carbide (MXene) nanosheets with a slide-ring polyrotaxane to form an internal mechanically-interlocked network. This inorganic matrix nanocomposite fiber featured distinct strain-hardening mechanical behavior and exceptional load-bearing capability (toughness approaching 60 MJ m −3 and ductility over 27%). It retained 100% of its ductility after cyclic strain loading. Moreover, the high electrical conductivity (>1.1 × 10 5 S m −1 ) and electrochemical performance (>360 F cm −3 ) of the nanocomposite fiber can be well retained after subjecting the fiber to extensive (>25% strain) and long-term repeated (10 000 cycles) dimensional changes. Such superior robustness allowed for the fabrication of the nanocomposite fibers into various robust wearable devices, such as textile-based electromechanical sensors with strain-unalterable sensing performance and fiber-shaped supercapacitors with invariant electrochemical performance for 10 000 strain loading cycles.

Progress toward the development of wearable electromechanical sensors with durable and reliable sensing performance is critical for emerging wearable integrated electronic applications. However, it remains a long-standing challenge to realize...