Critical thinking is one of the skills that must be possessed in the 21st century. These skills can be improved by using the right media in learning. This study aims to examine the effectiveness of lipid metabolism’s Flip PDF Professional’s electronic module (e-module) in problem-based learning to improve students’ critical thinking skills. The e-module used in this study was previously made by researchers and published. The research data process used non-parametric Wilcoxon match pair test with research instruments test critical thinking skills in the form of pre-test and post-test. Instrument tests are made based on the achievement of subject learning and critical thinking indicators that have been tested for content validation by expert. The subjects in this study were third-level students in Chemistry Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta. After the Wilcoxon match pair test with SPPS was obtained value Asymp. Sig. (2-tailed) is worth 0.000 < 0.05. This means that there is an increase in students’ critical thinking skills in pre-test to post-test after learning with method Problem Based Learning with the lipid metabolism e-module media.

Pembelajaran abad 21 pada era revolusi industri 4.0 menuntut inovasi dan pemanfaatan teknologi secara optimal. Penelitian ini bertujuan menghasilkan modul elektronik (e-modul) biokimia pada materi metabolisme lipid menggunakan aplikasi Flip PDF Professional. Metode yang digunakan adalah penelitian dan pengembangan model Borg dan Gall, instrumen penelitian berupa angket. Modul elektronik yang dibuat terdiri dari pendahuluan, pembahasan materi (katabolisme lipid, anabolisme lipid, kolesterol, serta penyakit terkait metabolisme lipid), video, gambar serta tes formatif pada tiap materi yang sesuai dengan capaian pembelajaran mata kuliah biokimia pada materi metabolisme lipid. Modul elektronik sudah divalidasi oleh ahli materi, bahasa, dan media; dilakukan uji coba lapangan dalam skala kecil terhadap 20 mahasiswa dan dosen biokimia. Hasil penelitian menunjukkan e-modul yang dibuat memiliki interpretasi baik dari ahli materi, bahasa, dan media dengan persentase 83,35% hingga 85,00%. Hasil uji coba lapangan juga menunjukkan modul tersebut mendapatkan interpretasi yang baik dengan persentase 84,39%. Melalui hasil uji coba dapat disimpulkan bahwa modul elektronik memiliki kategori baik serta mendapat respon positif mahasiswa dan dosen. Diseminasi modul elektronik pada proses pembelajaran biokimia sedang dilaksanakan dan akan dipublikasikan pada artikel selanjutnya.

Two chalcone derivatives, 2'-hydroxychalcone (1) and desmethylinfectocaryone (2), together with five known phenolic compounds infectocaryone (3), cryptocaryone (4), kurzichalcolactone A (5), pinocembrin (6) and trans-N-feruloyltyramine (7), were isolated from the methanol extract of the wood of Cryptocarya konishii. The structures of the new compounds were determined based on the analysis of spectroscopic data, including UV, IR, 1D and 2D NMR, and mass spectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of compounds 1-7 showed that compounds 2-4 strongly inhibited the growth of murine leukemia P-388 cells, whereas compound 4 significantly inhibited the enzyme.

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