No abstract

Valproic acid (VPA) is commonly used drug to treat variety of anticonvulsant and mood stabilizer in psychiatric and neurologic cases. It is thought to be a safe drug with a large therapeutic aspect..Uncommonly, hyperammonemia can be progressed by the usage of valproate and VPA induced hyperammonemia delirium-like condition by extrahepatic origin can be constituted. Being unrecognized of this situation in a timely manner can result in encephalopathy and even death. The measurement of the level of ammonia is important to establish a potentially lethal but reversible situation. In this case study, it is aimed that to present hyperammonemia related to the use of psychotropic drugs and to present a patient with hyperammonemia during VPA and antipsychotic use without a medical disease except bipolar disorder in the past.

SUMMARYValproic acid (VPA) is commonly used drug to treat variety of anticonvulsant and mood stabilizer in psychiatric and neurologic cases. It is thought to be a safe drug with a large therapeutic aspect..Uncommonly, hyperammonemia can be progressed by the usage of valproate and VPA induced hyperammonemia delirium-like condition by extrahepatic origin can be constituted. Being unrecognized of this situation in a timely manner can result in encephalopathy and even death. The measurement of the level of ammonia is important to establish a potentially lethal but reversible situation. In this case study, it is aimed that to present hyperammonemia related to the use of psychotropic drugs and to present a patient with hyperammonemia during VPA and antipsychotic use without a medical disease except bipolar disorder in the past.

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