Background: Multiple pregnancies are prone to be associated with adverse maternal and perinatal outcome. The incidence of multiple pregnancies has shown a significant increase over the last decades. Aim of the Study: This study aimed to describe the maternal and perinatal outcomes in multiple pregnancies delivered in a tertiary care hospital, Bangladesh. Methods: This was a prospective observational study; 23 patients were enrolled and analyzed. The study conducted with 23 women with twin pregnancies, over 2 year’s months from January 2020 December 2021 in the department of Gynecology and Obstetrics, Chittagong Medical College and Hospital, Chittagong, Bangladesh. Result: Out of 23 cases, 8 patients had intrapartum complications like PPH, mal-presentation, cord prolapse, low-lying placenta, and placental abruption. In this, 4(23.53%) had mal-presentation, and only one had PPH. These intrapartum complications were also categorized according to their chronicity. Mal presentations were seen in 23.53% of DCDA and 33.3% of MCDA with p=0.47. Both were not statistically significant, as shown in Table 4. These twin-specific complications were noted according to their chronicity. Discordant twin was seen in 11.76% of DCDA and 16.67% MCDA. Single IUD in 7.9% of DCDA. The complications and outcomes of the study population; more than 65% of patients needed NICU. In our study, we noted 4 perinatal death caused by intrauterine death, twin-to-twin transfusion syndrome, birth asphyxia, and respiratory distress. Conclusion: Majority of the multiple pregnancy is high risk one. So, all multiple pregnancies need early diagnosis, adequate antenatal, intra-natal and post-partum care to improve the outcome and should have mandatory hospital delivery.

Background: Early pregnancy failure is a common complication of pregnancy. If women do not abort spontaneously, they will undergo medical or surgical treatment in order to remove the products of conception from the uterus. Curettage, although highly effective, is associated with a risk of complications; medical treatment with misoprostol is a safe and less expensive alternative. Unfortunately, after 1 week of expectant management in case of EPF, medical treatment with misoprostol has a complete evacuation rate of approximately 50%. Misoprostol treatment results may be improved by pre-treatment with mifepristone; its effectiveness has already been proven for other indications of pregnancy termination. The study objective was to compare the outcome of Mifepristone alone with the Mifepristone- Misoprostol combination regimen for the management of IUFD.Methods: This was a Prospective clinical trial at the department of obstetrics and gynecology, Chittagong Medical College Hospital, Chittagong. From March 2016 (Actual patient enrolment started after obtaining ethical clearance i.e. March 2018) to September 2018.Results: A subjects delivered earlier than group B and the mean induction delivery interval in Group A is significantly less in comparison to Group B (p=<0.001). Out of 50 women, 2(4%) and 10(20%) women in Groups A and B required oxytocin infusion to establish good contractions, and completion of termination who regarded as a failure. In the mifepristone alone group, the success rate is significantly higher than in the combination group.Conclusions: The efficacy of mifepristone alone was found superior to that of the mifepristone misoprostol combination regimen in the present study.

Introduction: There should be a gap between pregnancies for the sake of both mother and child. Post-partum contraceptive is required to delay pregnancy after delivery and to pursue family planning. Aim of the study: The aim of this study was to evaluate the knowledge and practice of post-partum contraceptives in pregnant women. Methods: This cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, Khulna Medical College, Khulna, Bangladesh during the period from January 2019 to December 2020. Result: In this study, the mean age was 25.91 years (SD± 4.97 years) ranging between 16-39 years. In this study, most of the pregnant women (69%) did not get any postpartum FP during the hospital discharge. In this study, most of the pregnant women (77%) had ANC in their last pregnancy. In this study, most of the pregnant women (76%) did not get postpartum family planning counseling during ANC checkups. For most of the pregnant women (84%), the resumption of menstruation after the last pregnancy was less than 6 months. In this study, the current pregnancy of most of the study people (76%) was unplanned/unintended. There was no unplanned pregnancy loss (abortion) between last and current pregnancy for most of the pregnant women (80%). For most of the pregnant women (76%), the gap between last and current pregnancy was 1-2 years. In this study, most of the pregnant women (79%) did not have adequate knowledge and practice of contraceptives. Most of the pregnant women (14%) did not use any contraceptive due to a lack of knowledge. Followed by 10% did not use due to ignorance, 4% did not use due to irregular meetings with husband and 3% did not use as the family did not allow. In this study, most of the pregnant women (31%) did not use any method for postpartum contraceptives after the last pregnancy. Followed by, 20% used POP, 17% used condom, 15% used OCP, 10% used injection, 3% used PPIUD, 3% used LAM and 1% used implant. Conclusion: Most pregnant women do not have adequate knowledge and practice of contraceptives. Most pregnant women do not use any post-partum contraceptives. Women, using post-partum contraceptives, prefer POP, condoms, and OCP. The husband is the decision-maker for contraceptive usage in most cases.

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Background: Recurrent pregnancy loss (RPL) is an emotionally painful occurrence for couples and presents Obstetricians with a difficult clinical problem. Because a primary etiology cannot be determined in roughly half of the instances, it is irritating for both patients and obstetricians. The present study aimed to determine the association of the antithrombin III gene (SERPINC1) mutation with unexplained RPL.Methods: This case-control observational study was conducted at the out-patient department of feto-maternal medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, with a total sample size of was 68, with 34 in the control group and 34 in the case/RPL group.Results: The mean±standard deviation (SD) age of the RPL group was 28.44±5.25, and in the control group it was 29.15±4.72. The mean±SD body mass index (BMI) was 24.95±3.48 and 23.69±4.07 in RPL and control groups respectively. Among the RPL group patients, 68% (23) had the primary RPL, and 32% (11) had a second pregnancy loss.Conclusions: 5.88% of the cases have a heterozygous mutation which might be the cause of their RPL. There was no homozygous mutation was found for G878A in the case group. The allele for G878A was also higher in the case group. But these differences were statistically non-significant. So, to clarify this association with unexplained RPL, further research is necessary including multi-centre and large sample sizes.