The effectiveness of various therapeutic methods on bone fracture has been demonstrated in several studies. In the present study, we tried to evaluate the effect of local low-magnitude, high-frequency vibration (LMHFV) on rat tibia fracture in comparison with pulsed electromagnetic fields (PEMF) during the healing process. Mid-diaphysis tibiae fractures were induced in 30 Sprague-Dawley rats. The rats were assigned into groups such as control (CONT), LMHFV (15 min/day, 7 days/week), and PEMF (3.5 h/day, 7 days/week) for a three-week treatment. Nothing was applied to control group. Radiographs, serum osteocalcin levels, and stereological bone analyses of the three groups were compared. The X-rays of tibiae were taken 21 days after the end of the healing process. PEMF and LMHFV groups had more callus formation when compared to CONT group; however, the difference was not statistically significant (P = 0.375). Serum osteocalcin levels were elevated in the experimental groups compared to CONT (P ≤ 0.001). Stereological tests also showed higher osteogenic results in experimental groups, especially in LMHFV group. The results of the present study suggest that application of direct local LMHFV on fracture has promoted bone formation, showing great potential in improving fracture outcome. Bioelectromagnetics. 38:339-348, 2017. © 2017 Wiley Periodicals, Inc.
Introduction: This study aimed to investigate the clinical effect of Low Magnitude High Frequency Vibration (LMHFV) on nonunion tibial fractures, noninvasively. Methods: The Experimental (n=5) and control (n=5) groups were age-matched and pooled based on the Nonunion Tibia Score System (NUSS) (p>0.05). LMHFV (0.35g, 50 Hz, 20 minutes x 4/day) was applied to the experimental group for three months by a mechanical stimulator that we developed using a ‘clamp method’. The control group was followed during three months without any application other than routine treatment. The results were evaluated using the Radiographic Union Score for Tibial Fractures (RUST) and American Orthopedics Foot and Ankle Score (AOFAS). No statistically significant difference was observed between the groups at the beginning and in the end of the 3- month application for RUST and AOFAS scores (p>0.05). Results: Pain and function assessment, at the beginning and end of the study, as a part of The AOFAS scorewere not statistically different (p>0.05) in the control group. However, increases in pain and function AOFAS scores were statistically significant in the experimental group at the end of the 3- month application (p
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