Este é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que o trabalho original seja corretamente citado. Resumo: Introdução: A população que (sobre)vive nas ruas se caracteriza, muitas vezes, pela ruptura dos vínculos sociais e pelo uso de drogas, necessitando de cuidados de saúde e de assistência social. Objetivo:Identificar e analisar as percepções dos profissionais terapeutas ocupacionais e dos usuários sobre a atuação e especificidade da terapia ocupacional junto às pessoas em situação de rua atendidas pelo Centro de Atenção Psicossocial álcool e drogas (CAPS-ad III) e pela Unidade de Acolhimento (UA). Método: Trata-se de um estudo exploratório, de abordagem qualitativa, realizada a partir de entrevistas semiestruturadas com três terapeutas ocupacionais e cinco usuários de um CAPS-ad III do Distrito Federal e da UA referenciada por este CAPS-ad III; os dados foram analisados a partir do método de Análise de Conteúdo. Resultados: Os dados foram organizados em três categorias temáticas: (1) uso de drogas, a situação de morador de rua e o tratamento no CAPS-ad III;(2) o cotidiano de atuação da terapia ocupacional; e (3) terapia ocupacional e reinserção social. Conclusão:A terapia ocupacional atua com população em situação de rua com olhar para o cotidiano e desempenho de Atividades de Vida Diária (AVD), trabalhando na perspectiva da Redução de Danos como forma de buscar uma maior qualidade de vida dos usuários. Torna-se necessário levar espaços de saúde e de assistência social para o contexto do usuário, realizar ações extrapolando o espaço físico do CAPS-ad e colocando o usuário como participante ativo desse processo. Palavras-chave: População em Situação de Rua, Drogas de Abuso, Terapia Ocupacional.Abstract: Introduction: The population that lives (survive) on the streets is often characterized by the rupture of social ties and the use of drugs, necessitating health care and social assistance. Objective: To identify and analyze the perceptions of the occupational therapist professionals and the users about the performance and specificity of the occupational therapy with the street people assisted by the community-based drug treatment service (CAPS-ad III) and the Embracement Unit (EU). Method: This is an exploratory and qualitative study based on semi-structured interviews with 3 occupational therapists and 5 users of a CAPS-ad III from the Federal District and the Embracement Unit (EU) referenced by this CAPS-ad III; the data were analyzed using analysis content. Results: The data were organized into three thematic categories: (1) drug use, homelessness and treatment in CAPS-ad III; (2) the daily routine of Occupational Therapy; (3) Occupational Therapy and Aspectos do cuidado integral para pessoas em situação de rua acompanhadas por serviço de saúde e de assistência social: um olhar para e pela terapia ocupacionalHarm Reduction as a way to seek a higher quality of life of users. It...

The NUP214::ABL1 fusion is the second most common translocation involving the gene ABL1, after BCR::ABL1. It is a cryptic fusion in conventional karyotype, but detectable by molecular methods with specific probes. 8 It can be seen in B cell acute lymphoblastic leukemia (ALL) and less common in T cell ALL. 9,10 ABL1-a tyrosine kinase protein-is localized in 9q34.13 and NUP214-a component of the nuclear pore complex-in 9q34.12. There is a model that NUP214::ABL1 formation comes from a circularized region that segregated unequally during cellular division. 8 It is included in the Ph-like ALL group and may benefit from the use of tyrosine kinase inhibitors (TKI) such as dasatinib. [11][12][13] It is not seen among AML patients. There is just one previous case of NUP214::ABL1 in a 42-year-old patient in China. 14 This is the second description of the NUP214::ABL1 rearrangement found in AML, the first in the pediatric population. The lack of molecular methods availability impairs AML stratifying and this case was only better elucidated with the NGS on relapse. Even if other methods like protein chain reaction or fluorescence in situ hybridization were available, in this case, it hardly would be more enlightening, as this fusion is not routinely screened in AML. Moreover, his final classification is still defined by differentiation, as it is not otherwise specified. Perhaps there will be more cases described in the future, as the molecular tools become more accessible. Collecting cases like this one is extremely important for better understanding and discussing target therapies in future. The benefit of the use of TKI in this case remains an unanswered question. The more the stratifying tools are available worldwide, the better we will be able to personalize treatment. ACKNOWLEDGMENTSThe family gave written informed consent for archiving material in a biobank, for molecular profiling and clinical studies. It has the approval by the Ethics Committee of Federal University of São Paulo.

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Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. It is located mainly in the head and neck, extremities and trunk, rarely achieving the biliary tract (1%). The clinical presentation is characterized by obstructive jaundice, abdominal pain and palpable mass. The prognosis is favourable when being early diagnosed. The main differential diagnosis is the choledochal cyst. We bring a case report about a patient with biliary tract rhabdomyosarcoma, diagnosed and treated for 1 year as choledochal cyst, presenting obstructive jaundice for one year. A hepatic biopsy was done, showing hepatic fibrosis. He presented clinical worsening and was referred for liver transplant. An exploratory laparotomy was done before planning the transplant, which showed a biliary tract mass, followed by a biopsy. The anatomopathological result was RMS. Biliary tract RMS is a rare entity that should be included in the differential diagnosis of obstructive jaundice in children. Because of its similarity with choledochal cyst, pediatricians and surgeons should consider this hypothesis, for adequate investigation and treatment.