Thirty-two male Wistar rats were used to verify the effects of chronic noni (Morinda citrifolia L) juice administration on glycemia, triglycerides levels and its relation to physical performance. In addition, it was verified if chronic noni supplementation is safe to clinical use through the kidney morphology analysis. In half of the rats, diabetes mellitus (DM) was induced with STZ. All rats were submitted to an incremental workload running test (IWT) until fatigued so that oxygen consumption and performance indexes (exercise time to fatigue and workload) could be analyzed before noni administration. Then, the control and DM groups received placebo (saline solution) or noni juice (dilution 2:1) at a dose of 2 mL/kg once a day for 60 days. The result was four groups: control + placebo (CP), control + noni (CN), DM + placebo (DMP), and DM + noni (DMN). Groups were then given a third IWT to verify the effect of the noni juice on exercise performance and glycemia. Twenty-four hours after the third test, all animals were euthanized and blood and kidneys were removed for posterior analysis. Noni administration improved the time to fatigue and workload in DM rats by reducing hyperglycemia. These results could be associated with an improved energy efficiency promoted by noni ingestion. However, our results provided evidence that chronic noni administration causes kidney damage since elevated glomerular filtration was observed at the same magnitude as the non-treated DM group. In conclusion, chronic noni ingestion promoted glycemic control and improved the performance in DM rats but caused kidney toxicity.

INTRODUÇÃOA água é um bem natural, e a existência dos seres vivos depende diretamente desse bem, que é limitado, necessário à manutenção da vida, suporte dos ecossistemas e considerado direito fundamental universal (FLORES, 2011; LINO, 1998).A quantidade de água disponível no planeta causa uma falsa impressão de ser um recurso inesgotável; mas, do volume total encontrado no planeta 97,5% é do tipo salgada, encontrada nos oceanos e mares, enquanto apenas 2,5% correspondem à água doce, presente em rios, lagos, geleiras e subsolo. Desta quantidade, 68,9% encontra-se nas regiões polares em forma de geleiras, 29,9% no subsolo em aquíferos e somente 0,3% são águas dos rios e lagos disponível para consumo, porém a fração contaminada ainda é desconhecida (ALMEIDA, 2010). Palavras-chave:Água. Análise microbiológica. Ibirité. Detecção Rápida EnZquik. ResumoO córrego Barreirinho, objeto desse estudo, situado no município Ibirité-MG, vem sendo utilizado pela população do entorno principalmente para irrigação de hortaliças, mas a qualidade microbiológica do mesmo ainda não foi avaliada. O objetivo deste estudo foi avaliar os parâmetros físico-químicos e microbiológicos da água deste córrego e compará-los com os padrões da Resolução N°357 do CONAMA. A metodologia utilizada foi a técnica de tubos múltiplos e análise com o Kit de Detecção Rápida EnZquik. Os resultados das análises deste estudo demonstraram que os pontos próximos à nascente e no meio do curso d'água, com irrigação das hortas, mostram resultados semelhantes; as águas nesses pontos podem ser utilizadas para irrigação de hortaliças e consumo humano após tratamento simplificado. Os testes apontaram que no final do curso, na área urbana, a água é imprópria para qualquer uso. A semelhança entre os resultados obtidos com as duas técnicas permite sugerir que o Kit Enzquik, pode futuramente substituir técnicas utilizadas em laboratório, diminuindo o tempo de incubação e análise com outras metodologias, gerando um resultado quase instantâneo. AbstractThe Barreirinho stream, which is the object of this study, located in the city of Ibirité-MG, has been used by the surrounding population mainly for irrigation of vegetables, but the microbiological quality of the same has never been evaluated. The objective of this study was to evaluate the physical-chemical and microbiological parameters of the water of this stream and compare them with the standards of Resolution No. 357 of CONAMA (National Council of the Environment). The methodology used was the multiple tube technique and analysis with the EnZquik Quick Detection Kit. The results of the analyzes of this study showed that the points near the source (PN) and irrigation of the vegetable gardens (IH), are in agreement with the standards established by Resolution No. 357 of CONAMA, these points can be used for irrigation of vegetables and human consumption after simplified treatment. The tests pointed out that the DU (Urban Waste) point is unsuitable for any purpose. The similarity between the results obtained in this work s...

Thirty-two male Wistar rats were used to verify the effects of chronic noni juice administration on blood glucose levels and its relation to physical performance. In half of the rats, diabetes mellitus (DM) was induced with STZ, and the rats were submitted to an incremental workload running test (IWT) until fatigued so that oxygen consumption and performance indexes (exercise time to fatigue and workload) could be analyzed before noni administration. Then, the control and DM groups received a placebo (saline solution) or noni juice (dilution 2:1) at a dose of 2 mL/kg once a day for 60 days. The result was four groups: control + placebo (CP), control + noni (CN), DM + placebo (DMP), and DM + noni (DMN). All groups were then given a third IWT to verify the effect of the noni juice on exercise performance and glycemia. Twenty-four hours after the third test, all animals were euthanized and blood and kidneys were removed for posterior analysis. Noni administration improved the time to fatigue and workload in DM rats by reducing hyperglycemia. These results could be associated with an improved energy e ciency promoted by noni ingestion. However, our results provided evidence that chronic noni administration causes kidney damage since elevated glomerular ltration was observed at the same magnitude as the non-treated DM group. In conclusion, chronic noni ingestion promoted glycemic control and improved the performance in DM rats but caused kidney toxicity.