The antioxidant activity of food compounds is one of the properties generating the most interest, due to its health benefits and correlation with the prevention of chronic disease. This activity is usually measured using in vitro assays, which cannot predict in vivo effects or mechanisms of action. The objective of this study was to evaluate the in vivo protective effects of six phenolic compounds (naringenin, apigenin, rutin, oleuropein, chlorogenic acid, and curcumin) and three carotenoids (lycopene B, β-carotene, and astaxanthin) naturally present in foods using a zebrafish embryo model. The zebrafish embryo was pretreated with each of the nine antioxidant compounds and then exposed to tert-butyl hydroperoxide (tBOOH), a known inducer of oxidative stress in zebrafish. Significant differences were determined by comparing the concentration-response of the tBOOH induced lethality and dysmorphogenesis against the pretreated embryos with the antioxidant compounds. A protective effect of each compound, except β-carotene, against oxidative-stress-induced lethality was found. Furthermore, apigenin, rutin, and curcumin also showed protective effects against dysmorphogenesis. On the other hand, β-carotene exhibited increased lethality and dysmorphogenesis compared to the tBOOH treatment alone.
El conducto onfalomesentérico está presente desde la tercera semana y comunica la cavidad celómica con el intestino medio, la persistencia del conducto onfalomesentérico da lugar a un número de alteraciones dependientes del lugar donde se produce, sea intestinal o umbilical, se presenta el caso de una RN de sexo femenino en quien se observa un ombligo exudativo persistente, ante la sospecha clínica se realizan exámenes complementarios dentro de los cuales se emplearon estudios imagenológicos contrastados que demostraron una comunicación que posteriormente se definió como persistencia del conducto onfalomesentérico.
Recibido: 10-08-2017 / Aceptado: 12-09-2017
La hernia diafragmática congénita ocurre cuando el contenido abdominal protruye dentro de la cavidad torácica, debido a una alteración en el desarrollo embriológico del diafragma. Reportamos el caso de un neonato diagnosticado con hernia diafragmática congénita en nuestro servicio. La hernia produjo signos de dificultad respiratoria mientras permanecía en alojamiento conjunto, se estabilizó con apoyo de oxígeno para manejo quirúrgico en hospital de tercer nivel, donde fue sometido a reparación quirúrgica con buena evolución.
Recibido: 01-12-2017 / Aceptado: 25-01-2018
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