Two mixed breed dogs of 4 and 8 years old presented one cutaneous tumour each in the forelimb and lateral of the thorax. A cytopathological examination was performed and a transmissible venereal tumour was diagnosed. Six cycles of chemotherapy with vincristine sulphate at a dose of 0.75 mg/m 2 were given, resulting in a complete remission. The most common clinical presentation of transmissible venereal tumour in dogs is in vulva/vagina and penis/prepuce. Therefore, this case report draws attention for an extragenital presentation of this neoplasm, highlighting the importance of cytopathological examination for diagnosis, as well as in the definition of therapeutic approach and prognosis. K E Y WO R D S chemotherapy, transmissible venereal tumour, vincristine sulphate