Dear Editors, Epidermolysis bullosa pruriginosa (EBP) ([OMIM] 604129)is an uncommon clinical variant of dystrophic epidermolysis bullosa (DEB), described by McGrath in 1994 [1]. It is clinically characterized by intense pruritus, associated with pretibial lichenified or prurigo nodularis-like lesions, violaceous linear scarring, occasional trauma-induced blistering, excoriations, milia, nail dystrophy, and -in some casesalbopapuloid lesions on the trunk [1, 2]. Epidermolysis bullosa pruriginosa frequently poses a differential diagnostic challenge [3], and it may be clinically confused with other disorders [4,5]. We present eight cases of EBP and highlight the lag time between onset of symptoms and establishment of the correct diagnosis. Our report is aimed at aiding physicians in considering the possibility of this diagnosis when facing with its clinical manifestations, thus trying to avoid a delay in diagnosis.The charts of eight patients with EBP, followed at the Pediatric Dermatology Clinic of the Hospital das Clínicas of the University of São Paulo Medical School, were retrospectively reviewed. Clinical findings along with histopathology of routine hematoxylin-eosin stained sections and/or immunologic mapping (IM) confirmed the diagnosis in all patients. The latter was used to determine the level of cleavage [6]. Of these eight EBP patients, four were women and four were men, with ages ranging from 12 to 70 years. Two patients Conflict of interestNone.

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