BACKGROUNDLeprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae, which mainly affects the skin and peripheral nerves. Between 2016 and 2020, 155,359 new cases of this disease were diagnosed in Brazil. In addition to neuropathic pain, leprosy presents itself uncommonly in rheumatology practice in different ways, from arthritis to polyneuritis, and rheumatologists should be aware of this condition. Leprosy neuropathy is a situation which proper management must be broadly addressed, as it brings many harms to patients. CASES REPORT1) OFO, 40 years old, with leprosy for 4 years, type II multibacillary reaction, after 1 year it started with burning in the upper limbs accompanied by erythema nodosum and neuritis with bilateral ulnar nerve thickening. In addition to treating the underlying disease, he was treated for neuropathic pain with gabapentin 900 mg/day, codeine 120 mg/day, and amitriptyline 25 mg/day. There was a reduction in visual pain scale (VPS) from 10 (first visit) to 4 (current).2) MINK, 42 years old, with leprosy for 5 years, type I multibacillary reaction, started with paresthesias and burning in the lower limbs, with reduced muscle strength. Electroneuromyography showed axonal and sensory-motor demyelinating polyneuropathy of sensory predominance. She performed a sural nerve biopsy with a result of inflammatory neuritis and axonal demyelination. Treated with gabapentin 1,800 mg/day, codeine 120 mg/day and amitriptyline 25 mg/day. Initial VPS reduction from 10 to 4.3) LB, 40 years old, with leprosy for 8 years, type I multibacillary reaction, with burning and shock with paresthesia in the limbs. In use of carbamazepine 1,600 mg/day, methadone 40 mg/day and paracetamol 2,000 mg/day. Initial VPS reduction from 10 to 2. 4) SMG, 48 years old, with leprosy for 3 years. Multibacillary type I reaction, with allodynia with burning in the upper limbs and reduced muscle strength. Managed with duloxetine 60 mg/day, tramadol 200 mg/day and pregabalin 150 mg/day. VPS reduction from 9 to 3. CONCLUSIONLeprosy neuropathy is an important condition, given the varied manifestations and the impairment in the patient's quality of life. Knowledge about the proper management of this condition is of paramount importance, and tricyclic antidepressants represent a good choice, with amitriptyline being the most used. Carbamazepine, gabapentin and drugs with central analgesic potential can also be associated. Acting on pain is a physician's duty and a patient's right to improve quality of life and disease outcome.

Cryptosporidiosis is a parasitic disease caused by a protozoan called Cryptosporidium sp. An increased number of diagnoses were made in the last 20 years, especially in patients with immunodeficiency like the acquired human immunodeficiency syndrome and induced immunodeficiency, such as in transplant patients and those who need frequent hemodialysis, has been observed. We report the case of a young patient with ankylosing spondylitis treated with adalimumab who developed chronic diarrhea secondary to cryptosporidiosis