The inflammatory response is one of the complications of diabetic hypertensive patients with myocardial infarction (MI). The purpose of this study was to determine the diagnostic value of macrophage migration inhibitory factor (MIF) compared with high sensitivity C reactive protein (hs-CRP) in diabetic hypertensive patients presented with MI; and to determine the concomitant association between these factors in MI patients. For this purpose, 100 patients with MI were categorized into four groups, according to the existence of diabetes mellitus (DM) and/or hypertension (HTN), with 38 subjects with normal angiography considered as the control group. The levels of MIF and hs-CRP were estimated quantitatively using a sandwich enzyme-linked immunosorbent assay and a particle-enhanced immune turbidimetric assay, respectively. In addition, lipid profiles, hematological indicators, and certain clinical features were compared among the studied groups. The levels of MIF and hs-CRP increased significantly in MI patients compared to the controls (p<0.05). Additionally, the levels of MIF differed significantly between all MI groups and the control group (p<0.05). Although the group DM-HTN showed the highest MIF level within the MI groups, the difference was not significant (p>0.05). However, the hs-CRP level showed a significant difference (p<0.05). In addition, the MIF level correlated positively with hs-CRP, leukocytes, and neutrophils (p<0.05). Both MIF and hs-CRP levels correlated positively with age, body mass index (BMI), total cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-C) and non-high density lipoprotein (HDL), but they correlated negatively with HDL-C. According to the results, although MIF was a valuable diagnostic marker for MI, the hs-CRP showed to be a better prognostic indicator than MIF in diabetic hypertensive patients that presented MI.Palabras clave: diabetes mellitus; hipertensión; factor inhibidor de la migración de macrófagos; proteína C-reactiva de alta sensibilidad; infarto de miocardio.Resumen. La respuesta inflamatoria es una complicación del infarto de miocardio (IM) en pacientes diabéticos hipertensos. Este estudio se realizó para determinar el valor diagnóstico del factor inhibitorio de la migración de macrófagos (MIF) en comparación con la proteína C reactiva de alta sensibilidad (hs-PCR), en pacientes diabéticos hipertensos con IM; y también para precisar la asociación concomitante entre estos factores en pacientes con IM. Con este propósito, 100 pacientes con IM se clasificaron en cuatro grupos, de acuerdo con la existencia de diabetes mellitus (DM) y/o hipertensión (HTN) y 38 sujetos con angiografía normal se consideraron como el grupo control. Los niveles de hs-PCR y MIF se estimaron cuantitativamente utilizando un ensayo inmunoabsorbente ligado a enzimas y un ensayo inmunoturbidimétrico mejorado con partículas, respectivamente. Además, se compararon entre los grupos del estudio, los perfiles lipídicos, parámetros hematológicos y algunas características clínicas específ...

Background and objective: Coronary artery disease is a chronic inflammatory disease in which many risk factors and inflammatory mediators, including macrophage migration inhibitory factor, are involved. This study aimed to estimate macrophage migration inhibitory factor level in coronary artery disease patients in regard to age, gender, and smoking. Methods: A total of 138 coronary artery disease patients and 38 coronary artery disease free control subjects were admitted to surgical specialty hospital-cardiac center in Erbil city, Iraq between January and December 2017. Plasma macrophage migration inhibitory factor concentration was measured by enzyme linked immunosorbent assay. Results: Patients and controls were categorized into subgroups according to age (<55 and ≥55 years), gender (women and men), and smoking status (smokers and non-smokers). Macrophage migration inhibitory factor level in every coronary artery disease subgroup (age, gender, and smokers) patients increased significantly compared to the same control subgroups (P <0.05). Macrophage migration inhibitory factor level showed a higher level in coronary artery disease patients subgroups (≥55 years, female, smokers) compared to their corresponding coronary artery disease subgroups (<55 years, male, and non smokers). Macrophage migration inhibitory factor demonstrated a significant positive correlation with fibrinogen and high sensitivity C-reactive protein, insignificant positive correlation with age, total cholesterol, low density lipoprotein, and insignificant negative correlation with high density lipoprotein-cholesterol (P >0.05). Conclusion: This study demonstrated the diagnostic value of macrophage migration inhibitory factor elevation in coronary artery disease patients if compared with coronary artery disease free subjects, meanwhile suggesting that age, gender, and smoking had no direct role in macrophage migration inhibitory factor elevation considering their secondary minor contributions in macrophage migration inhibitory factor circulation. Keywords: Coronary; Macrophage; Age; Gender; Smoking.

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