Acute appendicitis is an infection that occurs in vermiform appendix, and because of that it needs to do appendectomy immediately. Appendectomy is included in clean contaminated operation category which allows Surgical Site Infection (SSI). The antibiotics use in post-surgical patients to prevent the infections. The aims of this study to identify profile and determine the quantity and quality of antibiotics use. This study used cross sectional study with retrospective data on patient’s medical records after surgery for acute appendicitis in General Hospital Pasuruan Regency on January-December 2018. Data analysis was performed descriptively. The result of this study showed that the highest profile of the antibiotic use for mono therapy was Cefuroxime (25.81%) and for combination therapy were Phosphomycin + Metronidazole (8.06%) and Ceftriaxone + Metronidazole (8.06%). The quantity of antibiotics use by using Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) method was obtained total DDD value 52.01 DDD/100 patient-days with the highest antibiotic was Metronidazole parenteral route 14.00 DDD/100 patient-days. Antibiotics included in Drug Utilization 90% (DU 90%) segment were (Metronidazole, Ceftriaxone, Phosphomycin, Cefuroxime, Gentamicin) by parenteral route. The quality of antibiotics use based on the Infectious Disease Society of America (IDSA) Guidelines, appropriate indication (11.86%), appropriate dose (52,54%), appropriate interval (22,03%), appropriate route (96.61%) and appropriate duration of treatment (28.81%).

Red fruit ( Lam.) contains high levels of fatty acids, α-tocopherol, and β-carotene which can accelerate wound healing. Red fruit oil (RFO) is formulated as an emulgel because it is comfortable to use, has high penetration, and has a low risk of irritation. Emulgel RFO must meet the standards for physical properties and stability of topical preparations.The purpose of this study was to determine the effect of variations in RFO concentration on the physical properties and physical stability of the RFO emulgel. Emulgel was made with various RFO concentrations of 5% w/v (F1), 10% w/v (F2), and 15% w/v (F3). Then there was a physical evaluation and tested for physical stability after storage for 28 days at room temperature (30ºC±2ºC). Variations in RFO concentration decreased dispersion and adhesion values in the evaluation of physical qualities. In the 28-day storage stability test, variations in RFO concentration decreased the pH value, dispersion and increased adhesion. Emulgel RFO before and after the cycling test did not change. After performing the mechanical test, all the RFO emulgels did not occur in phase separation. It can be concluded that the variation of RFO concentration affects the physical properties, namely, dispersion and adhesion. However, it did not affect the organoleptic, homogeneity, and pH of the emulgel. After 28-day storage, variations in RFO concentration significantly affected pH, spreadability, and adhesion, while homogeneity and organoleptic had no significant effect. Variations in RFO concentration did not affect the stability of the cycling test and mechanical test.

Monosodium Glutamate (MSG) is a food seasoning that is widely used. Consumption of MSG in excessive doses can cause an excess of free radicals in the body that trigger oxidative stress and finally affect the reproductive system hormones. These free radicals can be suppressed by administration of antioxidants. Rhizomes of Curcuma xanthorrhiza extracts containantioxidants and they are widely grown. Theyare used as traditional medicine in Indonesia. This experiment was conducted to investigatewhether rhizomes of Curcuma xanthorrhiza extracts areable to inhibit decreasing endometrial thickness in female mice after receiving orally MSG-treatment.This research adoptedtrue experimental posttest only control group design. It includes 25 mice that were divided into 5 groups: control K1 (CMC) and K2 (MSG), treatment group (MSG and rhizomes of Curcuma xanthorrhiza extracts with dose of 0,4 mg/gBW, 0,8 mg/gBW, 1,2 mg/gBW).In addition, the mice's endometrium were removed to be subsequently stained using Hematoxillin-Eosin. Thickening of uterus was observed and measured with 40x magnitude using Microphoto Microscope Olympus. Data was analized using One Way ANOVA. The research finally comes with a result showing that there were not any significant differences discovered from the endometrium thickening from the five tested groups (p>0,05). Therefore, it is implied that rhizomes of Curcuma xanthorrhiza extracts has no effect on endometrial thickness of uterus by oral MSG-treatment.

Background: The purpose of this study was to examine the relationship between knowledge, preventive behavior, and self-efficacy on mental health in professional football athletes during the Covid-19 pandemic. Methods: This research uses quantitative methods. This type of research is observational with a cross sectional approach. In this study, researchers will take data on the dependent variable and the independent variable at the same time. This research was conducted by distributing a questionnaire consisting of 4 parts, namely a knowledge level questionnaire sheet, a preventive behavior questionnaire sheet, a self-efficacy questionnaire sheet, and a mental health questionnaire sheet. Resultts: Based on the results of research on knowledge about covid-19, the majority of respondents, namely 44 people (55%) had a good level of knowledge related to COVID 19, 30 people (37.5%) had sufficient knowledge and only 6 people (7.5%) who have a low level of knowledge. While knowledge of preventive behavior, the majority of respondents 44 people (55%) have a good level of preventive behavior against covid-19, 33 people (41.25%) are sufficient and 3 people (3.75%) are lacking. Then knowledge about mental health, all respondents (100%) have normal mental health and no respondents are included in the category of anxiety disorders. While the results of self-efficacy, the average self-efficacy score of respondents was 4.28. The average score of 4.28 shows that the respondents' confidence in preventing the transmission of COVID-19 during the pandemic is quite high, although it has not yet reached the highest score. Conclusion: Based on the results of the study, it can be concluded that there is a significant relationship between self-efficacy and the mental health of the respondents.