This paper aims to examine the effect of conventional bank interest rates (CBIR), profit-sharing rates (PS), the level of liquidity proxied in the finance-to-deposit ratio (FDR) and the inflation rate (IR) against mudharabah deposits (MDs). The sample comes from eight Islamic public banks registered in the Financial Services Authority (OJK) and Bank Indonesia (BI) for the period from 2013 to 2017. The research uses a data panel regression analysis using EViews 8 to test the significance of tribal-level influence on conventional bank interest, profit-sharing growth rate, liquidity level and inflation rate. The results provide evidence that conventional interest rates do not affect MDs; the profit-sharing rate has a significant positive effect on MDs; the FDR has a positive effect on MDs, and the IR does not affect MDs. The results can increase our understanding of the variables that affect the volume of MDs. The results of this research have practical implications for people who will invest, giving them a better basis for making deposit and investment decisions by looking at interest rates and profit-sharing systems that are in line with Islamic investment principles that apply no uncertainty (Garar), interest (Riba) and gambling (Maisir) investments to cover all aspects of life (way of life).