The use of modified tibial plateau leveling osteotomy adapted for correction of the lateral patellar dislocation was effective, allowing simultaneous treatment of lateral patellar luxation and cranial cruciate ligament deficiency.
Purpose:
To evaluate whether using platelet-rich plasma (PRP) in the graft recipient
bed after the resection of a neoplasia can influence its recurrence because
this product stimulates angiogenesis, mitogenesis and chemotaxis.
Methods:
A study with 30 rats Wistar (
Rattus norvegicus albinus
),
which were separated into group A (induction of carcinogenesis, PRP in the
postoperative period) and group B (induction of carcinogenesis, absence of
PRP in the postoperative period), with 15 animals in each. Carcinogenesis
was induced on the skin of the animals’ chest by the topical application of
0.5% dimethylbenzantracene (DMBA) diluted in acetone. After surgical
resection of the induced neoplasia, PRP was used to stimulate angiogenesis
before surgical wound synthesis. Data on the control and experimental groups
and macroscopic and microscopic variables were evaluated using analysis of
variance and the Tukey’s test (5%).
Results:
It was possible to determine that the use of PRP is good in reconstructive
surgeries, but it is contraindicated in patients during tumor resection, as
it can cause changes in the surgical bed, in addition to stimulating
recurrences and metastases.
Conclusions:
PRP may interact with tumour cells that were in the recipient site of the
surgical wound during the resection of a neoplasia, and a local recurrence
process can be triggered by applying this product.
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