The COVID-19 pandemic is a problem for almost all countries in the world. Each country has its ways and obstacles in dealing with COVID-19. Indonesia is no exception, which has classified the COVID-19 pandemic as a non-natural disaster and each region has the authority to deal with each region effectively. Jember district, as a world carnival city, tries to deal with handling from upstream to downstream or from the smallest level so that it is considered more effective. This study aims to provide input for Kabupaten Jember government to overcome the Pandemic with a cultural approach that is in line with handling efforts from upstream. The world view of culture in Kabupaten Jember is considered capable of being applied by various levels of society as well as health workers and the Kabupaten Jember government. The research method used is qualitative with library data. The methodical elements used are analysis by using data reduction steps, data classification, data display, and interpretation and interpretation of data to obtain conclusions. The results were obtained by applying several categories of worldviews of the Jember Pendalungan culture. This worldview can be applied to health efforts ranging from health promotion, prevention, curative, and rehabilitation. The worldview of the Pendalungan culture is an approach for health workers and the government to get closer to the community to provide education and support for recovery from the COVID-19. The world view can be considered capable of handling the COVID-19 pandemic in a cultural approach in Kabupaten Jember. It can also be implemented in other areas according to local wisdom.