Clinical recognition of Cerebral Amyloid Angiopathy is difficult due to clinical and imagiological heterogeneity. The Modified Boston Criteria for diagnosis of ‘probable Cerebral Amyloid Angiopathy’ pathologically validated in 2010 had an increase in sensitivity with only a modest decrease in specificity. Following case illustrates a diagnostic challenge to an elderly patient with vascular risk factors, neurodegenerative symptomatology with multiple cerebral vascular lesions (ischemic and hemorrhagic, without lobar hemorrhage). The use of a non-invasive amyloid marker would be useful in atypical clinical courses of patients with Cerebral Amyloid Angiopathy.

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