Aim: To  identify  the  reactions  of  children  during  intravenous drug  administration  before  and  after  the  use  of  a  therapeutic  play  technique  and  to analyse their companions’ perceptions regarding the technique’s effects on the child’s preparation  for  intravenous  drug  administration.  Method:  An  exploratory  study  with  a qualitative approach conducted through observations of intravenous drug administration and  therapeutic  play  sessions  with  children  and  semi-structured  interviews  with  their companions.  The  data  were  subjected  to  thematic  analysis.  Results:  Children  who  had difficulty  accepting  intravenous  medication,  especially  those between  4  and  6  years, presented positive behavioural changes after the use of therapeutic play. The children’s companions recommended the use of this technique to improve care and reduce stress during   drug   administration.   Conclusion:   Therapeutic   play   is a   relevant   nursing intervention for minimizing children’s reactions during intravenous drug administration, and the training of nurses and the promotion of technique are important for improving care.