The climate of the Arabian Peninsula is characterized by significant spatial and temporal variations, due to its complex topography and the large-scale atmospheric circulation. Furthermore, the role of dust in the formation of regional climate is considered to be crucial. In this work, the regional climatology for the Arabian Peninsula has been studied by employing a high resolution state of the art atmospheric model that included sophisticated physical parameterization schemes and online treatment of natural aerosol particles. The simulations covered a 30-year period (1986–2015) with a temporal resolution of 3 h and a spatial distance of 9 km. The main focus was given to the spatial and temporal variations of mean temperature and temperature extremes, wind speed and direction, and relative humidity. The results were evaluated using in situ measurements indicating a good agreement. An examination of possible climatic changes during the present climate was also performed through a comprehensive analysis of the trends of mean temperature and temperature extremes. The statistical significant trend values were overall positive and increased over the northwestern parts of the examined area. Similar spatial distributions were found for the daily minimum and maximum temperatures. Higher positive values emerged for the daily maxima.