The objective of this work was to evaluate the effect of Sulfur at 30 CH combined with allopathic treatment in canine demodicosis, in the municipality of Camagüey, Cuba. The investigation was carried out, with dogs that received treatment for skin diseases, belonging to the municipality of Camagüey, Cuba. An open, non-sequential, randomized phase II clinical trial was conducted from a sample of 60 canines of both sexes, of the breeds: Pit Bull, Shar Pei, German Shepherd; Dalmatian and Mestizo, aged between two months and two years; classified as sick animals due to demodicosis, during the 2013-2016 period; The experimental population was divided into two randomized groups, each group consisting of 30 canines. A Chi-square analysis was performed to compare the proportions of the groups in the study according to the asymptomatic, improved, recurrence categories. The combination of Sulfur at 30 CH with allopathic medications proved to be effective in the recovery of animals, not showing recurrence in treated patients, demonstrating that homeopathic remedies act on vital energy. It was shown that the use of homeopathic remedies Sulfur at 30 CH, combined with allopathic drugs was effective in the recovery of animals affected by Demodex canis, not showing recurrence.