Single-cell manipulation is considered a key technology in biomedical research. However, the lack of intuitive and effective systems makes this technology less accessible. We propose a new tele–robotic solution for dexterous cell manipulation through optical tweezers. A slave-device consists of a combination of robot-assisted stages and a high-speed multi-trap technique. It allows for the manipulation of more than 15 optical traps in a large workspace with nanometric resolution. A master-device (6+1 degree of freedom (DoF)) is employed to control the 3D position of optical traps in different arrangements for specific purposes. Precision and efficiency studies are carried out with trajectory control tasks. Three state-of-the-art experiments were performed to verify the efficiency of the proposed platform. First, the reliable 3D rotation of a cell is demonstrated. Secondly, a six-DoF teleoperated optical-robot is used to transport a cluster of cells. Finally, a single-cell is dexterously manipulated through an optical-robot with a fork end-effector. Results illustrate the capability to perform complex tasks in efficient and intuitive ways, opening possibilities for new biomedical applications.

Single cell manipulation is considered a key technique for biological application. However, the lack of intuitive and effective systems make this techniques less widespread. We propose here a new tele-robotic solution for dexterous cell manipulation through optical tweezers. The slave robot consist in a combination of robot-assisted stages and a highspeed multi-trap technique and allows the manipulation of more than 15 optical traps in a workspace of (200×200×200) µm 3 for translations and (70×50×8) µm 3 for rotations, both with nanometric resolution. The master device with 6+1 Dof is employed to control the 3D position of optical traps in differents arrangements. Traps can be grouped and controlled in a variety of ways for specific purposes. Precision and efficiency studies are carried out with trajectory control tasks. Finally, the 6D teleoperated-control of an optical robot for cell-transport is presented. Results exemplify the kind of biological applications that can be accomplished with the presented system in an effective and intuitive way, even if the user does not come from an engineering background.

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En voulant réunir les notions de troubles neurodéveloppementaux ( tnd ) ou de troubles du spectre autistique ( tsa ) en particulier et le silence, on se heurte à plusieurs notions apparemment contradictoires mais si complémentaires. En passant du silence inexistant et stressant, lorsque l’on évoque les atypies perceptives des personnes tsa, comme l’hypersensibilité auditive, par exemple, au silence incompréhensible et destructeur lié à l’absence de transmission des connaissances, des savoirs et aux manques des formations initiales. Sans oublier le silence pesant, angoissant et tout aussi inexplicable induit par ce manque de mise à jour des connaissances et des avancées sur l’autisme dans les formations et la communication. Cet article traitera donc chacun de ces éléments en apportant, malgré beaucoup d’interrogations, certaines réponses pour à la fois rompre ce silence si déroutant et destructeur et rendre plus facile sa perception et sa compréhension.