Background and Objectives: Cervical cancer is a leading cause of cancer death in female populations. It is a virally induced carcinoma resulting from sexually transmitted high risk Human Papillomavirus infections (e.g. . Previous studies have shown associations between IL-17A levels in cancer micro-environments and metastasis of tumor cells. In Africa, chemotherapy (CT) is the standard first-line treatment for cervical cancer and the prognosis remains poor for metastatic and recurrent cases. The impact of CT as a treatment option is still unclear. We investigated the prognostic relevance of IL-17A profiles in Cervical cancer patients (CP) patients treated with cisplatin in combination with 5-fluouracil (5FU) for three cycles. Methods: The study included 57 CP and 59 women with no history of malignancy as healthy controls (HC). IL-17A plasma levels were evaluated by ELISA. For each CP, three blood samples were collected at three-week intervals before initiation of the chemotherapy protocol. Results: Before chemotherapy CP showed higher serum levels of IL-17A compared to HCs (p = 0.035). No relation was detected between age and IL-17A levels. We observed a significant increase in serum IL-17A during treatment of the CP group (p < 0.05). Depending on chemotherapy's efficacy, CP were divided into 1) non responders, 2) partial responders and 3) good responders. Non-responders patients showed significantly higher serum levels of IL-17A during the follow-up compared to partial and good responder groups both following the How to cite this paper:

Background: Antibodies to merozoite surface antigens (MSPs), the primary targets of malaria vaccine research, are associated with low malaria morbidity. However, few studies have looked at the implications of their variations on the evolution of clinical-biological forms of severe malaria.Methods: This cross-sectional, prospective, and analytical study evaluates by ELISA the IgG responses directed against the antigens MSP1, MSP4-20 and MSP4-40 of P. falciparum during severe malaria in patients hospitalized in the infectious diseases department of Fann university hospital from October 1, 2017, to November 30, 2019.Results: A total of 86 patients were selected. The average age of patients was 34 ± 17 years. Renal (74.4%), neurological (63.9%) and hepatic (55.8%) impairment were the main forms of severity. The mean hemoglobin level was 11.2 ± 3 g/dL with low parasitaemia (< 0.5%) in 80% of cases. In the evolution, 10 patients deceased achieving a lethality of 11.6%. The presence of associated diagnosis and comorbidity was linked to low levels of anti-MSP4-40 IgG (p = 0.032) and anti-MSP1 (p = 0.037), respectively. The number of failures per patient increased with the fall in the levels of anti-MSP1 IgG (p = 0.017) and MSP4-20 (p = 0.04). Only high levels of anti-MSP4-40 IgG were statistically associated with low lethality (p = 0.037). Conclusion:Anti-MSP1, MSP4-20, and MSP4 antibodies are involved in the anti-plasmodial humoral response in severe malaria. Their blood levels can serve as prognostic biomarkers for an optimal management.