Background: A consensus exists that the first author and corresponding author make the most contribution to the publication of an article. The Y-index has been proposed to assess the scientific achievements of authors, institutions, and countries/regions (AIC/R for short) based on the number of first-author publications (FPs) and corresponding-author publications (RPs). Nonetheless, the Y-index is defined in terms of count and radian (represented by j and h) instead of using the relative radius and angle degree to simplify understanding. In the literature, a method for drawing radar diagrams online with the Y-index is also lacking. This study was conducted to enhance the Y-index with an additional relative radius denoted by k and the angle degree represented by h* (named Yk-index), include easy-to-use features (e.g., copying and pasting) for the delivery of the online Radar-Yk, and identify which one of AIC/R contributed the most to a scientific journal. Methods: From the Web of Science (WoS) database, we downloaded 9498 abstracts of articles published in the journal of Medicine (Baltimore) in 2020 and 2021. Three visual representations were used, including a Sankey diagram, a choropleth map, and a radar diagram, to identify the characteristics of contributions by AIC/R to Medicine (Baltimore) using the Yk-index (j, k, h*). A demonstration of Rada-Yk with easy-to-use features was given using the copy-and-paste technique. Results: We found that Qiu Chen (China), Sichuan University (China), China, and South Korea (based on regions, e.g., provinces/metropolitan areas in China) were the most productive AIC/R, with their Yk equal to 27,715, 12415.1, and 2045, respectively; a total of 85.6% of the published articles in Medicine (Baltimore) came from the 3 countries (China, South Korea, and Japan); and this method of drawing the Radar-Yk online was provided and successfully demonstrated. Conclusion: A breakthrough was achieved by developing the online Radar-Yk to show the most contributions to Medicine (Baltimore). Visualization of Radar-Yk could be replicated for future academic research and applications on other topics in future bibliographical studies.

The health care sector has become increasingly interested in developing personal health record (PHR) systems as an Internet-based telehealthcare implementation to improve the quality and decrease the cost of care. However, the factors that influence patients’ intention to use PHR systems remain unclear. Based on physicians’ therapeutic expertise, we implemented a web-based infertile PHR system and proposed an extended Technology Acceptance Model (TAM) that integrates the physician-patient relationship (PPR) construct into TAM’s original perceived ease of use (PEOU) and perceived usefulness (PU) constructs to explore which factors will influence the behavioral intentions (BI) of infertile patients to use the PHR. From ninety participants from a medical center, 50 valid responses to a self-rating questionnaire were collected, yielding a response rate of 55.56%. The partial least squares (PLS) technique was used to assess the causal relationships that were hypothesized in the extended model. The results indicate that infertile patients expressed a moderately high intention to use the PHR system. The PPR and PU of patients had significant effects on their BI to use PHR, whereas the PEOU indirectly affected the patients’ BI through the PU. This investigation confirms that PPR can have a critical role in shaping patients’ perceptions of the use of healthcare information technologies. Hence, we suggest that hospitals should promote the potential usefulness of PHR and improve the quality of the physician-patient relationship to increase patients’ intention of using PHR.

The primitive data showed that adjunctive low-dose aripiprazole could augment the efficacy of regular-dose sertraline in fresh major depressive disorder. A large-scale study is needed to confirm this finding.

The aim of the present study was to examine the effect of ultra-low-dose naloxone on pertussis toxin (PTX)-induced thermal hyperalgesia in rats and its underlying mechanisms. Male Wistar rats, implanted with an intrathecal catheter with or without a microdialysis probe, received a single intrathecal injection of PTX (1 mg in 5 ml saline). Four days after PTX injection, they were randomly given a different dose of naloxone (either 15 mg or 15 ng in 5 ml saline), followed by a morphine injection (10 mg in 5 ml saline) after 30 min. The results found that PTX injection induced thermal hyperalgesia and increasing excitatory amino acid (EAA; L-glutamate and L-aspartate) concentration in the spinal CSF dialysates. Ultra-low-dose naloxone not only preserved the antinociceptive effect of morphine but also suppressed the PTX-evoked EAA release as well. Moreover, ultra-low-dose naloxone plus morphine administration inhibited the downregulation of L-glutamate transporters (GTs) and the L-glutamate-metabolizing enzyme glutamine synthetase (GS), and, moreover, inhibited microglial activation and suppressed cytokine expression in PTX-treated rat spinal cords. These results show that ultra-low-dose naloxone preserves the antinociceptive effect of morphine in PTX-treated rats. The mechanisms include (a) inhibition of pro-inflammatory cytokine expression, (b) attenuation of PTX-evoked EAA release, and (c) reversion of the downregulation of GT expression.

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