The new coronavirus (2019-nCoV) appeared in late 2019 in Wuhan, Hubei Province, China. 1 Since then, thousands of cases have been reported in China, in many other countries and in the European Union, including Greece. Data on the epidemiological and clinical features of the 2019-nCoV virus infection are growing rapidly while the number of cases and deaths is increasing every day worldwide. The first case in Greece appeared on February 26, 2020. On March 11, 2020, due to virus infection outbreak, Greek government decided firstly the closure of all educational structures and then on 13th March, the suspension of the operation of cafes, museums, shopping malls, sports facilities, restaurants, esthetics centers, etc According to Greek National Health Organization, all the cases that have been confirmed as COVID-19 until 20th April 2020 were 2245 (56% are men) and 116 dead. The median age of death was 74 years and 90.5% had an underlying disease and/or age, above 70 years. 2

Ultraviolet radiation exposure is the dominant environmental determinant of all major forms of skin cancer, and the main cause of prematurely aged skin that is referred to as photoaging. Collagen type I (COL I) is expressed differently along with the dermis between healthy and pathological skin tissues. The aim of this study was to understand the impact of solar radiation in the dermis and assess the impact of solar radiation to COL I. The hematoxylin and eosin staining protocol was performed in tissue paraffin blocks and then they were stained immunohistochemically with the rabbit monoclonal anti-COL I antibody. A total of 270 slides were studied with an Olympus BX 41 microscope; we scored positively the expression of COL I in dermis and statistically analyzed with IBM SPSS Statistics. Based on our results, we observed that solar elastosis changes the structure of the skin’s collagen. In healthy tissues, COL I had a uniform expression along with the dermis. In tissues with aging, COL I expression was weaker and lost homogeneity. In pathological tissues (non-melanoma skin cancers, NMSCs), precancerous lesions, and benign skin lesions), the expression of COL I was observed to be almost weaker than tissues with aging in all body parts and much weaker below the lesions. The most severe solar elastosis was observed in the extremities. The degree of severity of the solar elastosis in relation to age did not appear to be completely affected. Solar radiation divides the collagen more rapidly than normal biological aging and solar elastosis was observed into the skin tissues with photoaging, which replaces the collagen fibers of the skin. These results confirm previous studies, which have shown that skin COL I decreases during aging, more in photoaging and even more in skin cancers. We conclude that skin COL I expression is reduced as a result of ultraviolet radiation and leading to negative impacts on the skin.

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Both endogenous and exogenous factors cause skin aging. This study aimed to compare the differential expressions of collagen type I (COL I) and collagen type VI (COL VI) in skins with biological aging and photoaging. In order to comprehend the impact of solar radiation in the dermis and the expression of COL I and COL VI, we studied the expression and their detection in healthy skin and in skin that had been characterized by aging. The hematoxylin and eosin staining protocol was performed in tissue paraffin blocks and they were then stained immunohistochemically with rabbit monoclonal anti-COL I and anti-COL VI antibodies. A total of 201 slides were studied with an Olympus BX 41 microscope, and the expressions of COL I and COL VI in the dermis were scored on a scale of 1 to 5, and then positively and statistically analyzed with IBM SPSS Statistics software. The results show that solar elastosis changes the structure of the skin’s collagen and solar elastosis was observed in the skin tissues with photoaging without appearing to be affected by its appearance in relation to age. Solar radiation divides the collagen fibers more rapidly than normal biological aging and replaces the collagen fibers of the skin. COL I and COL VI are expressed differently along the dermis of healthy skin tissue and the skin tissue subject to photoaging.

This review emphasizes the significance of dietary carotenoids in promoting skin health and appearance. The applications of carotenoids in health-promoting and nutrient products and their potential health effects are discussed. Food technology, health, nutrition, dermatology, and dermoaesthetics have recently focused on colorless carotenoids, particularly phytoene, and phytofluene, which have the unique ability to absorb UV radiation. These carotenoids, being significant components of the human diet, are readily bioavailable and have demonstrated various health-promoting actions in re-cent studies. Their distinct structures and properties, such as light absorption, oxidation sensitivity, stiffness, aggregation tendency, and even fluorescence in the case of phytof-luene, contribute to their potential benefits. Furthermore, it is recommended to assess the levels of these carotenoids to evaluate skin carotenoid status accurately.