Background: Recent empirical literature on autoimmune diseases has focused extensively on the implementation and evaluation of psychosocial interventions. Psychotherapy and counselling processes for multiple sclerosis (MS) have gained special attention given the cognitive and behavioral dimensions of the symptoms as well as their unpredictable course. The current study aims to gain a deeper understanding of the meaning making processes for persons with MS (PwMS) who are in psychotherapy treatment. Method: The sample of this study consisted of ten PwMS who described their experience of the illness and of psychotherapy of choice through semi-structured interviews. Data collection and analysis adhered to Interpretative Phenomenological Analysis guidelines. Results: The results revealed that PwMS struggled with understanding the initial symptoms, contemplated taking medication, and related symptom development to psychological factors such as depression. Participants were preoccupied with disability representations and questioned the trustworthiness of their bodies. They worked towards integrating the illness into their identity and described how psychotherapy encouraged psychological agency whilst feeling supported and "accepted". Conclusions: Psychotherapy contributes to the processes of shaping participants' life worlds, offering a space to self-organize and reflect within genuine therapeutic relationships.