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Synthesis and characterization of nickel(II) meso-tetraarylporphyrins fused to imidazolium rings across [Formula: see text],[Formula: see text]-pyrrolic positions and X-ray structure of the porphyrin where two opposed pyrrole units are fused to an imidazolium ring are presented. The interactions between these mono-, bis-, tris- and tetrakis(imidazolium) porphyrins with human telomeric DNA G-quadruplexes (G4) were investigated using UV-vis absorption spectroscopy, Circular Dichroism (CD) spectroscopy and Fluorescence Resonance Energy Transfer (FRET) melting assay. Possible binding modes between cationic porphyrins and a selected G4 sequence (d[AG3(T2AG[Formula: see text]]), and relative stabilities of porphyrin/G4 complexes are discussed. Excepting porphyrins fused to one imidazolium ring, the other derivatives interact with G4 structures and their stabilization strongly depends on the porphyrin structure (number and localization of the imidazolium rings).

Ma s'io avessi previsto tutto questo, dati causa e pretesto, le attuali conclusioni Credete che per questi quattro soldi, questa gloria da stronzi, avrei scritto canzoni? Va beh, lo ammetto e mi son sbagliato e accetto il "crucifige" e così sia Chiedo tempo, son della razza mia, per quanto grande sia oh, il primo che ha studiato Ma s'io avessi previsto tutto questo, dati causa e pretesto, forse farei lo stesso Mi piace far canzoni e bere vino, mi piace far casino, poi sono nato fesso E quindi tiro avanti e non mi svesto dei panni che son solito portare Ho tante cose ancora da raccontare per chi vuole ascoltare e a culo tutto il resto Francesco Guccini, L'avvelenata TRAD: Frankly, if I had expected all of this, data reasons, pretexts and present conclusions. Do you think that for these four pennies, for this useless glory, would I have written songs? Okay, I admit I made a mistake, and I accept the Crucifixion and so be it. I ask for time, I am of my kind, as many as we are, the first who studied. But frankly, if I had expected all of these: data reasons and pretexts. Maybe I would make the same thing I love to make songs and to drink wine I love to party And also I am born a bloody idiot. And so I move on, and I don't shuffle Off the clothes I usually wear I have so many things to tell to anyone who will listen.