in Wiley InterScience (www.interscience.wiley.com).Regio-and stereo-controlled opening of 2,3-epoxy amines and 2,3-aziridine amines by the commercially available MgBr 2 is described. As reported, this new method could represent a general and useful approach for the preparation of promising intermediates. Moreover, in particular cases, the reaction evolves toward an interesting oxazolidin-2-one structure.

Starting from a suitably functionalized aziridine, a highly efficient stereoselective synthesis of (1R,2R)-phenyl-2-decanoylamino- 3-morpholinopropan-1-ol (D-threo-PDMP) is described. The approach, based on the ring expansion of the aziridine ring to oxazoline, could be applicable to the synthesis of many analogues with different amide chains and sugar mimic portions

MgBr 2 -Mediated Opening of 2,3-Three Membered Heterocyclic Amines. -The regio-and stereo controlled opening of 2,3-epoxy amines and 2,3-aziridine amines by MgBr2 is studied. This new method represents a general and useful approach to promising intermediates. -(RIGHI*, G.; CIAMBRONE, S.; ESUPERANZI, E.; MONTINI, F.; PELAGALLI, R.; J.