Interleukin-4 boosts the capacity of dendritic cells to present endogenous antigens on MHC II and to resist bacterial infection through a mechanism shown to be partially dependent on RUFY4 expression.
IL-12 is enriched at the immunological synapse in TLR-activated dendritic cells interacting with antigen-specific CD8+ T cells; synaptic delivery of IL-12 induces IFN-γ production in the T cell.
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