Featured Application: Halloysite nanotubes for surface cleaning. Controlled cleaning of a marble surface.Abstract: Halloysite nanotubes were used to incorporate anionic surfactant micelles and an organic solvent to generate a cleaning system to be applied in Cultural Heritage restoration. The targeted adsorption is driven by electrostatic interactions based on the nanotubes peculiar charge separation. Namely anionic species are driven to the positively charged inner surface while being prevented from interacting with the halloysite outer surface that possesses a positive charge density. The hybrid organic/inorganic emulsion was characterized by dynamic light scattering. Analysis of the autocorrelation function allowed us to define the presence of surfactant aggregates inside/outside the nanotube lumen as a function of the nanotube/surfactant ratio in an aqueous mixture. The application of this prepared emulsion for the controlled cleaning of a marble artifact is demonstrated. To this purpose, a membrane of nanofibrous polyacrylonitrile was prepared by electrospinning and was applied between the work of art and the cleaning agent to avoid the release of residues on the marble surface. This work represents a further step toward the opportunity to extend the use of emulsions for cleaning protocols for stone-based artifacts or in technological applications where surfactant separation is required by a simple centrifugation/sedimentation method. 2 of 10 with a significant reduction in toxicity and environmental impact. Restoration of the Renaissance paintings by Masaccio, Masolino, and Lippi in the Brancacci Chapel in Florence (1984)(1985)(1986)(1987)(1988)(1989)(1990) represents the first case study reporting the use of microemulsions for conservation purposes [2,3]. Recently, amphiphile-based systems were intensively studied by Piero Baglioni to remove synthetic materials (acrylic and vinyl polymers) from painted surfaces [4]. These results show that the designed nanostructures improved the traditional methods while both minimizing the environmental impact and the optimizing cleaning performance [4]. Disadvantages for the use of colloidal systems are related to the high wettability of the treated surface and to spreading within the substrate porosity. Small traces of surfactant that remain on the artwork may cause deterioration and, in some cases, lead to the complete disfiguration of painted surfaces [5]. A fascinating resolution is freezing the microemulsion dynamics into a rigid nanocontainer in such a way as to simplify the removal of the whole cleaning system [6].Among nanomaterials, hybrid systems prepared by a combination of mesoporous particles and sustainable polymers or surfactants are promising for several applications within materials science and biotechnology [1,[7][8][9][10][11][12][13][14][15]. Clay nanoparticles are promising as solid supports due to their sustainability and low cost [16][17][18][19][20]. Halloysite is an emerging hollow tubular clay which is naturally available worldwide and cheap co...